可溶性白细胞介素2受体在女性Graves病患者骨代谢中的作用  

The role of soluble interleukin 2 receptor in bone metabolism of Graves＇ disease in women

作　　者：王芸[1] 凌雁[1] 高鑫[1] 

机构地区：[1]复旦大学附属中山医院内分泌科,上海200032

出　　处：《中华内分泌代谢杂志》2017年第5期382-386,共5页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的研究女性Graves病（GD）患者外周血可溶性白细胞介素2受体（sIL2R）与骨密度、骨代谢指标的关系，探讨sIL2R在女性GD患者骨代谢中的作用。方法应用电化学发光法检测201例女性GD患者甲状腺功能指标（FT3、FT4、TSH）及骨代谢指标[PTH、骨钙素（OCN）、I型胶原C端肽（CTX）、I型原胶原N端前肽（PINP）、25-羟维生素D（250HD）]水平，化学发光法检测sIL2R水平。全部患者行骨密度检查，测定腰椎、总髋、股骨颈3个部位骨密度（LS—BMD、TH-BMD、FN—BMD）。分析sIL2R与骨代谢指标及骨密度的关系。结果分别按LS—BMD、TH—BMD、FN—BMD行三分位分组。OCN、CTX及PINP从第1三分位到第3i分位逐渐降低，组间差异均有统计学意义（均P〈0．05）；进一步分别按OCN、CTX、PINP行三分位分组，阿，及sIL2R从第1i分位到第3三分位逐渐升高（均P〈0．05）：多元线性回归显示sIL-2R与OCN、CTX独立相关（均P〈0．05）。结论女性GD患者骨转换增加导致其骨量丢失，外周血sIL2R水平与骨转换指标呈正相关，提示sIL2R在骨代谢过程中起重要作用。Objective To examine the relationship between plasma soluble interleukin 2 receptor（ sIL2R）, bone metabolism markers, and bone mineral densities in female patients with Graves＇ disease （ GD ） , and to explore the role of slL2R in bone metabolism of GD. Methods This study included 201 female GD patients. FT3 , FF4, TSH, PTH, osteocalcin （ OCN）, C-terminal telopeptides of type I collagen （ CTX）, procollagen type I N-terminal propeptide（PINP）, and 25-（ OH ）-vitamin D （25OHD） were measured using electrochemical luminescence technique, sII2R was measured using chemiluminescence method. All pations underwent examinations of bone mineral densities at lumbar spine, total hip, and femoral neck （ LS-BMD, TH-BMD, and FN-BMD）. The associations of sIL2R with bone metabolism markers and bone mineral densities were analyzed. Results OCN, CTX, PINP gradually decreased across the tertile groups of LS-BMD, TH-BMD, FN-BMD（ all P〈0.05 ）. FT3 , sIL2R gradually increased across the tertile groups of OCN, CTX, PINP（ all P〈0.05 ）. Multiple linear regression analysis showed that sIL2R was independently associated with OCN and CTX（ both P〈0. 05 ）. Conclusion The increase of bone turnover leads to bone loss in female GD patients. The plasma level of sIL2R was positively emTelated to bone turnover, which indicated that slL2R may play an important role in bone metabolism of GD.

关 键 词：格雷夫斯病 可溶性白介素2受体 甲状腺功能 骨密度 骨代谢 

分 类 号：R581.1[医药卫生—内分泌]