胰岛素原／胰岛素比值在糖尿病基础和临床研究中的意义  

Implication of proinsniin to insulin ratio in the basic and clinical research of diabetes

作　　者：刘珺玲 魏蕊[1] 洪天配[1] 

机构地区：[1]北京大学第三医院内分泌科,100191

出　　处：《中华内分泌代谢杂志》2017年第5期449-452,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81400798、81270858、81570692）;北京市自然科学基金资助项目（7163233）

摘　　要：胰岛素原是胰岛素的前体，胰岛素原／胰岛素比值可反映胰岛β细胞功能障碍的程度和2型糖尿病的进展，并可预测糖尿病的发生风险。某些糖尿病易感基因的变异与胰岛素原／胰岛素比值升高存在一定的相关性。此外，许多降糖药物可降低2型糖尿病患者的胰岛素原／胰岛素比值。因此，胰岛素尉胰岛素比值可作为糖尿病的病因学研究、风险评估、疾病进展及治疗评价的一个重要指标。Proinsulin is the precursor of mature insulin. Proinsulin to insulin ratio reflects the degree of pancreatic β-cell dysfunction and the progression of type 2 diabetes, and may predict the risk of diabetes development. Some variants in susceptibility genes of diabetes are associated with the elevation of proinsulin to insulin ratio. Moreover, several antidiabetic drugs are able to decrease the proinsulin to insulin ratio in patients with type ：2 diabetes. Therefore, the proinsulin to insulin ratio may act as a simple and useful indicator in the etiological study, risk prediction, disease progression and therapeutical evaluation in type 2 diabetes.

关 键 词：糖尿病 2型 胰岛Β细胞 激素原转化酶 胰岛素原 

分 类 号：R587.1[医药卫生—内分泌]