睾丸发育与精子发生相关miRNAs的研究进展  

Research Progress on miRNAs in Testis Development and Spermatogenesis

作　　者：白曼[1] 孙丽敏[1] 项露颉 贾超[1] 李佳蓉[1] 姜怀志[1] 

机构地区：[1]吉林农业大学动物科学技术学院,吉林长春130118

出　　处：《中国畜牧杂志》2017年第6期4-10,共7页Chinese Journal of Animal Science

基　　金：吉林省科技发展计划项目(20160204018NY)

摘　　要：miRNAs是一类广泛存在于真核生物中参与调节不同生物过程的非编码小RNA,可在转录后特异结合mRNAs 3'非翻译区降解靶mRNAs或抑制其翻译,调控其表达。miRNAs对精子发生的细胞特异性调控,对调节雄性生殖具有重要意义。本文概述了miRNAs的生物合成、作用机制,特别是miRNAs对睾丸组织发育及精子发生的表达调控,旨在为进一步深入研究miRNAs在雄性生殖中的作用及分子调控机制提供参考。miRNAs are a class of non-coding small RNA, which are widely existed in eukaryotes and involved in regulating different biological processes, miRNAs can degrade the target gene or inhibit the gene translation by targeting 3＇UTR of mRNAs at the post transcriptional level to regulate the expression of gene. The cell specific regulation of miRNAs in spermatogenesis is important to regulate male reproduction. This article reviewed the biosynthesis, mechanism and especially the expressions of miRNAs in testis development and spermatogenesis, which provides a reference for further research on the role and molecular regulation mechanism of miRNAs in male reproduction.

关 键 词：MIRNAS 生物合成 表达调控 睾丸发育 精子发生 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学]