结核病患者抗结核治疗后肝功能损害临床病例分析  

Clinical case analysis of liver function damage after antituberculosis therapy in tuberculosis patients

作　　者：钟静[1] 邹桂敏[1] 张志坚[1] 

机构地区：[1]广州市胸科医院,510195

出　　处：《中国实用医药》2017年第12期7-9,共3页China Practical Medicine

摘　　要：目的探讨抗结核药物性肝功能损害的病例特征和临床表现。方法收集410例结核病患者,分析患者发生抗结核药物性肝功能损害的临床特点及其相关因素。结果 410例结核病患者中,16.3%(67/410)发生肝功能损害,男性肝功能损害比例高于女性,差异有统计学意义(P<0.05);各年龄组间肝功能损害发生率比较差异无统计学意义(P>0.05);服药2个月内发生肝功能损害的患者比例高于服药>2个月的比例;肝功能损害无症状者占65.7%(44/67),具有发热和黄疸症状仅占4.5%。结论男性是肝功能损害的易患因素,尤其在治疗期的2个月内易发生;必须关注无症状肝功能损害病例,定期进行肝功能检测,并采取合适药物治疗措施,确保完成抗结核治疗疗程。Objective To explore the case features and clinical manifestation of anti-tuberculosis drug induced hepatotoxicity. Methods A total of 410 tuberculosis patients were collected, and analysis were made on clinical features of anti-tuberculosis drug-induced hepatotoxicity and its related factors. Results Among 410 tuberculosis patients, 16.3% （67/410） cases had liver function damage, and liver damage proportion in male was higher than that in female. The difference had statistical significance （P〈O.05）. There was no statistically significant difference in incidence of liver function damage in different age groups （＊o〉0.05）. Proportion of liver function damage within 2 months of meditation was higher than 2 months above of meditation. The asymptomatic cases accounted for 65.7% （44/67）, and fever and jaundice only accounted for 4.5%. Conclusion Male case is susceptible to liver function damage, especially within 2 months of treatment. Attention must be payed to asymptomatic liver function damage cases, and make liver function detection regularly, along with implement of appropriate drug treatment measures, so as to ensure complement of anti-tuberculosis courses.

关 键 词：抗结核药物 抗结核药物性肝功能损害 临床特点 

分 类 号：R52[医药卫生—内科学] R575[医药卫生—临床医学]