胺碘酮联合美托洛尔用于冠心病心律失常治疗疗效观察  

Observation on curative effect of amiodarone combined with metoprolol applied in the treatment of arrhythmia of coronary heart disease

作　　者：黄国虹 

机构地区：[1]茂名市中医院,525000

出　　处：《中国实用医药》2017年第12期9-11,共3页China Practical Medicine

摘　　要：目的观察美托洛尔联合胺碘酮用于冠心病心律失常治疗的疗效。方法 132例冠心病心律失常患者作为观察对象,按照不同治疗方法分为参照组和观察组,每组66例。参照组单纯予以胺碘酮治疗,观察组在参照组治疗基础上联合使用美托洛尔治疗。观察并比较两组临床疗效的差异性。结果治疗前两组收缩压(SBP)、舒张压(DBP)、心率(HR)比较差异均无统计学意义(P>0.05);治疗后观察组SBP、DBP、HR均优于参照组,差异均具有统计学意义(P<0.05)。观察组治疗总有效率为97.0%,高于参照组的81.8%,差异具有统计学意义(P<0.05)。观察组不良反应发生率为10.6%,与参照组的9.1%比较差异无统计学意义(P>0.05)。结论冠心病心律失常采用胺碘酮联合美托洛尔治疗,具有效果确切、安全有效的优点,值得临床借鉴和进一步使用推广。Objective To observe the curative effect of amiodarone combined with metoprolol applied in the treatment of arrhythmia of coronary heart disease. Methods A total of 132 arrhythmia oLcoronary heart disease patients as observation subjects were divided by different treatment methods into control group and observation group, with 66 cases in each group. The control group received amiodarone for treatment, and the observation group received metoprolol for treatment on the basis of the control group. Clinical curative effect differences was observed and compared in two groups. Results Before treatment, both groups had no statistically significant difference in systolic blood pressure （SBP）, diastolic blood pressure （DBP） and heart rate （HR） （P〉0.05）. After treatment, the observation group had better indexes of SBP, DBP and HR than the control group, and their difference had statistical significance （P〈0.05）. The observation group had higher total treatment effective rate as 97.0% than 81.8% in the control group, and the difference had statistical significance （P〈0.05）. The observation group had no statistically significant difference in incidence of adverse reactions as 10.6%, comparing with 9.1% in the control group （P〉0.05）. Conclusion Combination of amiodarone and metoprolol shows advantages of affirmative effect, safety and effectivity for arrhythmia of coronary heart disease. So it is worthy of clinical reference and further use and promotion.

关 键 词：心律失常 冠心病 胺碘酮 美托洛尔 

分 类 号：R541[医药卫生—心血管疾病]