不同类型Gn对IVF患者获卵及胚胎结局的初探  

Preliminary exploration of ovum and embryo outcome by useing different types of Gn in IVF patients

作　　者：王天琪[1] 孙振高[2] 杨毅[1] 王晓明[1] 徐凯月 宋景艳 张兴兴[1] 王爱娟[1] 苑丽华[1] 姜华颖[1] 肖继梅 撒元红 

机构地区：[1]山东中医药大学,济南250014 [2]山东中医药大学附属医院,济南250014

出　　处：《中国优生与遗传杂志》2017年第5期123-125,95,共4页Chinese Journal of Birth Health & Heredity

基　　金：国家自然科学基金;山东省科技发展计划项目编号:(81373676);(81674018);(2014GSF119021)

摘　　要：目的采取回顾性病例对照的研究方法,观察不同类型Gn在行体外受精-胚胎移植(IVF-ET)助孕患者中的应用,探讨不同类型Gn对IVF患者获卵及胚胎结局的影响。方法对243名因单纯输卵管因素行IVF长方案助孕患者新鲜周期获卵及胚胎结局进行回顾性分析,其中单纯用HMG进行COH 32例(A组),使用HMG+普利康进行COH77例(B组),使用HMG+果纳芬进行COH 134例(C组),对比三组的获卵结果及胚胎情况。结果 A组费用明显低于B组与C组,差异有统计学意义(P<0.05),在花费的情况下A组与B,C两组有相近的合格卵率、受精率、优质胚胎率,但差异均无统计学意义(P>0.05);与A组C组相比,B组具有较高的2PN卵裂率,差异有统计学意义(P<0.05);与A组B组相比,C组Gn用量较明显减少、Gn费用较多、获卵个数较多,且差异有统计学意义(P<0.05)。三组患者在年龄、不孕年限、BMI、基础卵泡刺激素(bFSH)、基础黄体生成素(bLH)、基础雌二醇(bE_2)、Gn天数等方面无显著差异(P>0.05)。结论对于IVF患者,使用不同类型的Gn可对获卵及胚胎结局产生不同的影响。Objective： To observe the application of different types of Gn in vitro fertilization-embryo transfer （IVF-ET） assisted pregnancy by retrospective case-control study, to explore the effect by different types of Gn on ovulation and embryo outcome of IVF patients.Methods： A retrospective analysis was conducted on 243 ovarian and embryo outcomes in 243 patients with IVF-long protocol assisted by simple tubal factors. 32 cases （group A） was treated with HMG alone and group B （77 patients） treated with HMG ＋Pulicron, （Group C） were treated with HMG ＋ Gnaphal, and the results of ovulation and embryo were compared between the three groups. Results： The cost of group A was significantly lower than that of group B and group C （P〈0.05） . In group A, the cleavage rate of 2PN and transplantable embryo between group A with group C was similar to those in group B （P〉 0.05） . Compared with group A and group C, the cleavage rate of 2PN in group B was higher, and the difference was significant （P〈0.05） . Compared with group A and group B, the amount of Gn in group C was significantly decreased, the cost of Gn was higher, the number of ovum was higher, and the difference was statistically significant （P〈0.05） . There were no significant differences in age, infertility, BMI, basal follicle stimulating hormone （bFSH） , basal luteinizing hormone （bLH） , basal estradiol （bE2） and Gn days in the three groups （P〈0.05） . Conclusions： Different types of Gn may have different effects on ovulation and embryo outcome in IVF patients.

关 键 词：Gn类型 体外受精-胚胎移植(IVF-ET) 长方案 获卵及胚胎结局 

分 类 号：R714.8[医药卫生—妇产科学]