老年冠心病患者血清VEGF、NT-proBNP、cTnT与冠状动脉病变程度的相关性  

Correlation between Serum Levels of VEGF,NT-proBNP,cTnT and the Severity of Coronary Arterial Lesions in Elderly Patients with Coronary Heart Disease

作　　者：颜文婷[1] 徐海燕[1] 魏忠诚[1] 

机构地区：[1]南京医科大学附属淮安第一医院心内科,江苏省淮安市223300

出　　处：《医学分子生物学杂志》2017年第2期96-99,共4页Journal of Medical Molecular Biology

摘　　要：目的 探讨老年冠心病（coronary atherosclerotic heart disease,CHD）患者血清血管内皮生长因子（vascular endothelial growth factor,VEGF）、氨基端脑肽前体（N-terminal pro-brain natriuretic peptide,NT-proBNP）、肌钙蛋白T（cardial troponin T,cTnT）与冠状动脉病变程度的相关性.方法 选取2015年8月~2016年8月南京医科大学附属淮安第一医院收治的113例老年CHD患者为观察组,同期选取64例体检健康老年人为本研究对照组,采用酶联免疫吸附试验（Enzymes linked immunosorbent assay,ELISA）检测所有受试者血清VEGF、NT-proBNP、cTnT水平,分析三者与老年CHD患者冠状动脉病变程度的相关性.结果 观察组血清VEGF、NT-proBNP、cTnT水平均明显高于对照组,差异有统计学意义（P〈0.05）;冠状动脉3支血管病变组血清VEGF、NT-proBNP、cTnT水平均明显高于2支及1支血管病变组（P〈0.05）,2支血管病变组血清VEGF、NT-proBNP、cTnT水平均明显高于1支血管病变组（P〈0.05）;Gensini积分≥30分组血清VEGF、NT-proBNP、cTnT水平均明显高于Gensini积分〈30分组（P〈0.05）;相关性分析结果可见,血清VEGF、NT-proBNP、cTnT水平与Gensini积分呈显著正相关（r=0.772,0.593,0.634,P〈0.05）.结论 老年CHD患者血清VEGF、NT-proBNP、cTnT与冠状动脉病变程度相关,且随着冠状动脉病变程度增加呈现明显升高趋势.Objective To investigate the correlation between serum levels of vascular endothelial growth factor （VEGF）,N-terminal pro-brain natriuretic peptide （NT-proBNP）,cardial troponin T （cTnT） and the severity of coronary arterial lesions in elderly patients with coronary heart disease （CHD）.Methods The study recruited 113 elderly CHD patients serving as the observation group,and 64 healthy elderly people as the control group.The levels of serum VEGF,NT-proBNP and cTnT were detected by ELISA,and the correlation between the three indices and the severity of coronary arterial lesions were analyzed.Results The levels of VEGF,NT-proBNP and cTnT were significantly higher in observation group than in control group （P〈0.05）.They were significantly higher in the observation group involving 3 vessel lesions than in that having 2 or 1 vessel lesion （P〈0.05）.Two vessel lesions group had increased levels of VEGF,NT-proBNP and cTnT as compared with 1 vessel lesion group （P〈0.05）.The Gensini score≥30 group had higher levels of VEGF,NT-proBNP,cTnT than the Gensini score〈30 group did （P〈0.05）.The levels of serum VEGF,NT-proBNP and cTnT were significantly positively correlated with Gensini score （r=0.772,0.593,0.634,P〈0.05）.Conclusion The serum levels of VEGF,NT-proBNP and cTnT are correlated with the degree of coronary arterial lesions in elderly patients with CHD,and they are significantly increased with the severity of coronary arterial lesions.

关 键 词：老年冠心病 血管内皮生长因子 氨基端脑肽前体 肌钙蛋白T 冠状动脉病变 

分 类 号：R541.4[医药卫生—心血管疾病]