左金丸血清药物化学研究  

Preliminary Study on Serum Pharmacochemistry of Zuojin Pill

作　　者：龚梦鹃[1] 周祥羽 岳贺[1] 李春苑[1] 王淑美[1] 梁生旺[1] 邹忠杰[1] 

机构地区：[1]广东药科大学中药学院/国家中医药管理局中药数字化质量评价技术重点研究室/广东高校中药质量工程技术研究中心,广东广州510006

出　　处：《中国民族民间医药》2017年第11期56-58,62,共4页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：国家自然科学基金青年基金项目(81403075;81603397)

摘　　要：目的:对左金丸血清药物化学进行初步研究,通过分析入血成分探讨左金丸在大鼠体内的药效物质基础。方法:通过比较左金丸水煎液、口服左金丸及单味生药大鼠血清和空白血清HPLC图谱,初步鉴定左金丸在大鼠血清中的移行成分。结果:口服左金丸水煎液后在大鼠血清中发现14个入血成分,其中5个为原型成分,9个为代谢产物。结论:该研究建立的方法可用于左金丸水煎液血清指纹图谱和药效物质基础研究。Objective To carry out a preliminary study on serum pharmacochemistry of Zuojin Pill and to further explore its pharmacoldynamic material basis through analyzing the constituents absorbed into blood. Methods The prototype components and metabolites in rat serum were identified through analysis and comparison of the HPLC fingerprints of Zuojin Pill, rat serum obtained after oral administration of zuojin Pill or single crude drug and blank serum. Results After rats were administered with Zuojin Pill, 14 transitional constituents in blood were detected, among which 9 were metabolites and 5 were prototype constituents. Conclusion The method established in this study can be used to research the serum fingerprint and material foundation of Zuojin Pill.

关 键 词：左金丸 血清药物化学 药效物质基础 

分 类 号：R284.1[医药卫生—中药学]