MEN-10,376对断尾小鼠ACG神经元Fos蛋白表达的影响  

Effect of MEN-10,376 on Fos Protein Expression of Neurons in Anterior Cingulate Gyrus Caused by Amputating the Mice Tail Extremity

作　　者：吴敏范[1] 马积昊 杨宇[1] 商丽宏[1] 李娜然[3] 张雅娟[4] 吴孟霏 

机构地区：[1]沈阳医学院基础医学院生理学教研室,辽宁沈阳110034 [2]辽宁何氏医学院 [3]形态学实验室 [4]沈阳市第五人民医院神经内科

出　　处：《沈阳医学院学报》2017年第3期196-197,200,共3页Journal of Shenyang Medical College

基　　金：辽宁省科技厅基金项目(No.L2015020391);沈阳市科技局计划项目(No.F13-220-9-45)

摘　　要：目的:探讨静脉注射NK-2受体拮抗剂MEN-10,376对断尾小鼠扣带回前部(anterior cingulate gyrus,ACG)神经元Fos蛋白表达的影响。方法:应用免疫组化技术研究静脉注射MEN-10,376对小鼠尾末端2.5 cm剪断后30 min ACG神经元Fos蛋白表达的影响。结果:与空白对照组比较,断尾小鼠ACG神经元Fos蛋白表达在断尾后30 min显著增高;MEN-10,376静脉注射抑制了断尾引起的ACG神经元Fos蛋白表达的显著增高(P<0.01)。结论:断尾小鼠ACG神经元Fos蛋白表达显著增高的过程有外周速激肽NK-2受体参与。Objective：To investigste the effect of intravenous injection of NK-2 receptor antagonist MEN-10,376 on Fos protein expression of neurons in anterior cingulate gyms （ACG） caused by amputating the mice tail extremity. Method： The effect of intravenous injection of MEN-10,376 on Fos protein expression of neurons in ACG at 30 min after amputating the mice tail extremity 2.5 cm was studied with immunohistochemistry method. Result： Compared with the control group, Fos protein expression of neurons in ACG at 30 min after the amputating increased remarkably, which was inhibited by intravenous injection of MEN-10,376（P〈0.01 ）. Conclusion： Peripheral tachykinin NK-2 receptors are involved in the process of remarkable increase in Fos protein expression of neurons in ACG of the amputated mice.

关 键 词：MEN-10 376 NK-2受体 扣带回前部 幻肢痛 FOS蛋白 

分 类 号：R338[医药卫生—人体生理学] Q432[医药卫生—基础医学]