紧急避孕药与异位妊娠发生的Meta分析  

Emergency Contraceptive and Risk of Ectopic Pregnancy:A Meta-analysis

作　　者：许晶[1] 莫念 白慧明[1] 郭荣[2] 

机构地区：[1]湖北中医药大学第一临床学院,湖北武汉430060 [2]湖北省中医院

出　　处：《沈阳医学院学报》2017年第3期258-261,共4页Journal of Shenyang Medical College

摘　　要：目的:系统评价口服紧急避孕药与异位妊娠发生的关系,为更好地预防异位妊娠的发生提供依据。方法:计算机检索Pub Med、Embase、Science Direct、中国知网(CNKI)、万方(Wan Fang)和维普(VIP)数据库。由2名研究者单独筛选文献、提取资料。采用NOS评价标准对纳入文献进行评价,用软件Rev Man5.3作Meta分析。结果:最终纳入14篇病例对照文献,其中病例组2 743例,对照组4 320例。Meta分析结果显示,口服紧急避孕药异位妊娠发生率合并效应量RR=2.45(95%CI:1.07~3.63),即口服紧急避孕药发生异位妊娠是正常妊娠的2.45倍,病例组和对照组差异有统计学意义(Z=4.45,P<0.01)。结论:口服紧急避孕药是导致异位妊娠发生的危险因素之一。Objective： To prevent the incidence of ectopic pregnancy, this paper systematically evaluates the relationship between oral emergency contraceptives and eetopic pregnancy. Methods： We searched PubMed, Embase, ScienceDirect, CNKI, WanFang and VIP databases for relevant papers. Two researchers separately searched the articles and extracted data from eligible studies independently. The quality of eligible literatures was assessed by Newcastle-Ottawa scale （NOS） . All statistical analyses were conducted using the Review Manager 5.3 software. Results： A total of 14 case-control studies with 2 743 cases and 4 320 controls were included in this mata-analysis. The results showed that there was significant association between oral emergency contraceptives and the incidence of ectopic pregnancy （RR=2.45, 95%CI： 1.07-3.63） （Z=4.45, P〈0.01） . Conclusion： Oral emergency contraceptive is one of the risk factors of ectopic pregnancy.

关 键 词：紧急避孕药 异位妊娠 左炔诺孕酮 米非司酮 META分析 

分 类 号：R714.22[医药卫生—妇产科学]