母牛分枝杆菌对复治涂阳肺结核患者防治的实践评价  

Practical evaluation of cow mycobacterium in the prevention and treatment of retreated smear-positive tuberculosis patients

作　　者：何侃珩 

机构地区：[1]江西省景德镇市第五人民医院,江西景德镇333000

出　　处：《中国现代医生》2017年第15期84-87,共4页China Modern Doctor

基　　金：江西省景德镇市科技计划项目(20162SFZC077)

摘　　要：目的探讨母牛分枝杆菌对复治涂阳肺结核患者的防治效果。方法选取我院在2013年3月~2015年4月收治的86例复治涂阳肺结核患者作为本次研究的对象,将其按入院时间分为观察组与对照组,每组43例。两组患者均给予常规治疗方案,观察组患者在此基础上加用母牛分枝杆菌进行治疗。对比两组患者治疗之后的X线变化、空洞闭合情况、治疗后各个时间段的痰菌转阴率、复发率。结果观察组患者的X线病灶明显吸收率为76.74%,空洞闭合率为72.09%;对照组患者的X线病灶明显吸收率为32.56%,空洞闭合率为34.88%;组间比较差异有统计学意义(P<0.05)。观察组患者在治疗后各个时间段的痰菌转阴率与对照组相比,差异有统计学意义(P<0.05)。对两组患者进行为期一年的随访,发现观察组复治涂阳肺结核的复发率为0.00%,对照组为11.63%,组间比较差异有统计学意义(P<0.05)。结论复治涂阳肺结核患者使用母牛分枝杆菌进行治疗,能够全面提高治疗的总有效率,促进患者的预后,使患者早日恢复正常生活,且母牛分枝杆菌具有一定的预防作用,能够阻止复治涂阳肺结核的再次复发,值得临床推广应用。Objective To study the effect of cow mycobacterium on the prevention and treatment of retreated smearm positive pulmonary tuberculosis patients. Methods A total of 86 patients with retreated smear-positive pulmonary tuberculosis who were treated in our hospital from March 2013 to April 2015 were enrolled in this study. The patients were divided into observation group and control group according to the time of admission, with 43 patients in each group. The two groups of patients were treated with conventional treatment program, and the observation group of pa- tients was also given cow mycobacterium on this basis. The X-ray changes, cavity closure case after treatment, and the sputum negative rate, recurrence rate in each time period after treatment between the two groups were compared. Results The obvious absorption rate of X-ray lesion .was 76.74% and the cavity closure rate was 72.09% in the observation group. The obvious absorption rate of X-ray lesion was 32.56% and the Cavity closure rate was 34.88% in the control group. The difference was statistically significant（P〈0.05）. There was significant difference＇ in the sputum negative rate between the observation group and＇the control group in each time period after treatment（P〈0.05）. Two groups of patients were followed for one year. The recurrence rate of retreated smear-positive puimonary tuberculosis in the observation group was 0.00% and the recurrence rate in the control group was 11.63%. There was significant difference between the two groups（P〈0.05）. Conclusion Treating retreated smear positive pulmonary tuberculosis patients with cow myeobacterium can comprehensively improve the total effective rate of treatment, promote the prognosis of patients to make patients return to normal life as soon as possible. And cow mycobacterium has a certain preventive effect, which can prevent the recurrence of retreated smear-positive pulmonary tuberculosis and is worthy of clinical application.

关 键 词：复治涂阳肺结核 母牛分枝杆菌 预防 痰菌转阴率 复发率 

分 类 号：R520.5[医药卫生—内科学]