脂联素与胰岛素抵抗研究进展  

Progress of the Relationship Between Adiponectin and Insulin Resistance

作　　者：安平[1] 王安平[1] 母义明[1] 

机构地区：[1]解放军总医院内分泌科,北京100853

出　　处：《生物技术通讯》2017年第3期360-365,共6页Letters in Biotechnology

摘　　要：脂联素是脂肪组织分泌一种脂肪因子,与胰岛素抵抗和肥胖密切相关,在2型糖尿病和肥胖人群中,脂联素的血浆浓度下降。脂联素信号通路通过激活AMPK和PPAR-α与胰岛素信号通路相联系。研究表明,上调脂联素信号通路的活性可以有效缓解胰岛素抵抗。因此,脂联素信号转导通路机制是以胰岛素抵抗为病理生理基础的2型糖尿病的研究热点。本文简要介绍脂联素的生物学特征、脂联素的信号通路机制、脂联素与胰岛素抵抗的现有研究成果及临床价值。Adiponectin, a protein secreted by adipose tissue, is considered that associated with insulin resistance and obesity. The reduction of adiponectin level was observed in people with insulin resistance. The insulin-sensitizing efforts of adiponectin resulting from the activation of AMPK and PPAR-α and the decrease of triglyceride level. Up-regulation of adiponectin signaling may be the potential treatment strategy of insulin resistance. This review aims to discuss the mechanisms of adiponectin related to insulin resistance and its perspective of clinical value.

关 键 词：脂联素 胰岛素抵抗 肥胖 

分 类 号：R335.6[医药卫生—人体生理学]