重症药疹112例分析  

Analysis of 112 Cases of Severe Drug Eruption

作　　者：余炳前[1] 王文菊[1] 骆志成[1] 

机构地区：[1]兰州大学第二医院,甘肃兰州730030

出　　处：《中国皮肤性病学杂志》2017年第6期623-626,共4页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨重症药疹的临床特点及治疗措施。方法对本科2011年4月-2016年3月收治的112例重症药疹患者进行回顾性分析。相关数据采用SPSS19.0软件进行统计学分析。结果平均开始激素量为(1.97±2.35)mg/kg;在治疗过程中有17例(15.18%)患者糖皮质激素加量,比不加量组平均激素总量大、平均住院日长、皮损好转时间长;糖皮质激素联合大剂量静脉注射用人免疫球蛋白治疗患者23例(20.54%),与单独使用糖皮质激素治疗组相比不能减少平均起始激素量和平均激素总量、不能缩短平均住院日及降低死亡率,但似乎可缩短皮损好转时间,预后好;经治疗痊愈51例(45.54%)、好转58例(51.79%)、死亡3例(2.68%)。结论重症药疹治疗要个体化,起始糖皮质激素用量应早期足量,早期联合大剂量静脉注射用人免疫球蛋白对危重患者的治疗似乎有帮助。Objective To investigate the clinical feature and treatment of severe drug eruption. Methods In our in-pa- tient-department from April 2011 to March 2016 a total of 112 patients diagnosed with severe drug eruption were analyzed retrospectively and SPSS19. 0 statistical analysis was used in data processing. Results Start- ing glucocorticoid dosage was （1.97 ± 2. 35）mg/kg, glucocorticoid dosage was increased in 17 eases （15. 18% ）in the treatment process,the total dosage was more than the group who were not increased the dosage, extended average length of stay in hospital, prolonged skin turnaround time ; Corticosteroids incombi- nation with large dose of intravenous immunoglobulin therapy in 23 cases （20. 54% ） cannot reduce the aver- age starting hormone or total hormone, cannot reduce the average length of stay in hospital or mortality, com- pared to the group that used cortieosteroid alone, the lesions improve in shorter time, and the prognosis was better;51 cases（45.54% ） cured, 58 cases（51.79% ）improved and 3 cases（2. 68% ） died. Conclusion Initial dosage of glucocorticoid should be early and sufficient, and carried on the individualized treatment ac- cording to patients condition. Early glucocortieoid in combination with large dose of intravenous immunoglob- ulin was probably helpful to the treatment of critically patients.

关 键 词：重症药疹 临床分析 糖皮质激素 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]