多种保湿剂对皮肤短期保湿效果的对比观察  

The Comparison of Short-term Effect of Several Moisturizers

作　　者：华薇[1] 曹畅[1] 李远西[1] 谢恒[1] 戴茹[1] 李祎铭[1] 熊丽丹[2] 李利[1,2] 

机构地区：[1]四川大学华西医院皮肤性病科,四川成都610041 [2]四川大学华西医院化妆品评价中心,四川成都610041

出　　处：《中国皮肤性病学杂志》2017年第6期682-686,共5页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨不同的统计方法是否会影响化妆品保湿功效评价的结果。方法 20名受试者前臂内侧和小腿外侧标记测试区域,各区随机接受空白、10%甘油、6种市售保湿霜处理,处理前、后测量角质层含水量。分别用自身前后对照、随机对照两种方法分析各产品的保湿效果。结果前臂和小腿各部位角质层水含量值较均一。两种统计方法分析结果有所不同,空白对照区的角质层含水量随时间有所改变,各产品在干燥组和正常组的保湿效果有差异。结论前臂和小腿是化妆品保湿功效评价较理想的部位。在用前后对照设计评价保湿功效时,空白对照区的变化应纳入考虑。Objective To investigate whether the different statistical methods could affect the accuracy of the moisturis- ing efficacy evaluation. Methods Test zones were marked on the forearms and shanks of twenty subjects. A glycerin aqueous solution, six moisturising products and blank control were randomly assigned. Stratum cor- neum hydration （SCH）was measured prior to and post application. Self-controlled method and randomized control method were used to statistically evaluate the moisturising efficacy. Results No statistical difference was observed between different anatomical regions on forearms or shanks. The results with two statistical methods were partly different, meanwhile hydration values on blank control were shifted over time. A differ- ence in product performance between normal skin group and dry skin group was observed. Conclusion Forearms and shanks are ideal positions for moisturising efficacy study. Change of blank control should be taken into consideration in the self-controlled study.

关 键 词：保湿 角质层含水量 统计方法 

分 类 号：R751[医药卫生—皮肤病学与性病学]