人类白细胞抗原DP基因多态性与特发性膜性肾病遗传易感性研究  

Association between HLA-DP polymorphisms and Idiopathic Membranous Nephropathy

作　　者：杨凤文[1] 冯忖[1] 陈文军[2] 臧倩男 袁国栋[1] 檀金川[1] 

机构地区：[1]河北省中医院肾病科,河北石家庄050011 [2]天津中医药大学,天津300193 [3]河北医科大学,河北石家庄050011

出　　处：《现代预防医学》2017年第11期2108-2112,共5页Modern Preventive Medicine

摘　　要：目的探讨人类白细胞抗原(human leukocyte antigen,HLA)DP基因多态性与中国人群特发性膜性肾病(Idiopathic Membranous Nephropathy,IMN)遗传易感性的关系。方法选取185例特发性膜性肾病患者和405位健康对照作为研究对象,应用Taq Man-MGB探针基因分型方法检测HLA-DP基因多态性位点(rs3077和rs9277535)的基因型分布。结果采用多因素logistic回归分析,rs3077位点结果显示,突变基因型AA在特发性膜性肾病组中的频率均显著高于健康对照组(调整OR=1.92,95%CI=1.09-3.38);单倍型分析显示,与GG单倍型相比,携带AA单倍型的个体可增加特发性膜性肾病的患病风险;(调整OR=2.86,95%CI=1.58-5.58);此外,rs3077位点的突变基因型AA可增加特发性膜性肾病患者发生肾功能衰竭的风险(调整OR=3.11,95%CI=1.53-6.32)。结论 HLA-DP基因多态性与特发性膜性肾病遗传易感性存在关联,且与特发性膜性肾病患者的肾功能也具有相关性。Objective To study the association HLA - DP polymorphisms and idiopathic membranous nephropathy. Methods 185 idiopathic membranous nephropathy patients and 405 healthy controls were enrolled in this study. The rs3077 and rs9277535 of HLA - DP gene were genotyped by using TaqMan - MGB technology among cases and controls. Results Logistic regression analyses showed that the mutant genotype AA of rs3077 significantly increased the risk of IMN （ adjusted OR = 1.92, 95% CI： 1.09 - 3.38 ）. Haplotype analysis also showed that （ adjusted OR = 2.86,95% （21 = 1.58 - 5.58 ）. Otherwise, rs3077 AA genotype patients showed higher risk of renal failure, compared with GG genotype patients. Conclusion HLA - DP genetic polymorphisms might be related to IMN susceptibility and associated with renal function in patients with IMN.

关 键 词：膜性肾病 特发性 HIA-DP 单核苷酸多态性 

分 类 号：R181.33[医药卫生—流行病学]