手性磷配体在不对称氢化碳碳双键中的发展和应用  

Chiral Phosphorus Ligands in Asymmetric Hydrogenation Development and Application of Carbon-carbon Double Bond

作　　者：陈海涛[1] 段显英[1] 王文新[1] 蒋卫鹏[1] 韩福娇[1] 李继[1] 

机构地区：[1]河南省科学院化学研究所有限公司,河南郑州450002

出　　处：《安阳师范学院学报》2017年第2期34-44,共11页Journal of Anyang Normal University

摘　　要：不对称催化氢化反应是合成光学活性物质的重要手段。手性磷配体在不对称催化氢化反应的发展中有着重要的作用。近十多年来,各种高效、高对映选择性的手性磷配体和催化剂被设计出来,并成功应用于不对称氢化反应。本文分别从手性单齿磷配体和手性双齿磷配体两个方面简要综述了手性磷配体在C=C双键不对称氢化反应中的发展和应用。Catalytic asymmetric hydrogenation is one of the most efficient methods for the synthesis of optical active compounds. Chiral phosphorus ligands have played an important role in the development of the catalytic asymmetric hydrogenation. During the past decades, many highly enantioselective chiral catalysts have been disclosed and successfully applied to the asymmetric hydrogenation. This review presents a brief overview on the progress in catalytic asymmetric hydrogenation of various unsaturated prochiral substates containing C = C double bond from two aspects： （1） chiral monodentate ligands （2） chiral biphosphine ligands.

关 键 词：手性单齿磷配体 手性双齿磷配体 不对称催化氢化 烯烃 

分 类 号：O621.3[理学—有机化学] O643.3[理学—化学]