活血化瘀方联合氯沙坦钾片治疗慢性肾小球肾炎临床观察  

Clinical Effect of Huoxue Huayu Prescription Combined with Losartan Potassium Tablets in Treatment of Chronic Glomerulonephritis

作　　者：张永刚[1] 李瑜琳[2] 杨国利[1] 王世兰[1] 张竟 曹灵 ZHANG Yong-gang LI Yu-lin YANG guo-li WANG Shi-lan ZHANG Jing CAO Ling(Department of Traditional Chinese Medicine, Qinghai Provincial People＇s Hospital, Qinghai Xining 810007, China Department of Nephrology, Qinghai Provincial People＇s Hospital, Qinghai Xining 810007, China Department of Nephrology, The Affiliated Hospital of South- west Medical University, Sichuan Luzhou 646000, China)

机构地区：[1]青海省人民医院中医科,青海西宁810007 [2]青海省人民医院肾内科,青海西宁810007 [3]西南医科大学附属医院肾病内科,四川泸州646000

出　　处：《安徽中医药大学学报》2017年第3期21-24,共4页Journal of Anhui University of Chinese Medicine

基　　金：国家自然科学基金项目(81170667)

摘　　要：目的探讨活血化瘀方联合常规西药干预慢性肾小球肾炎的临床疗效,为临床中西医结合治疗慢性肾小球肾炎提供依据。方法将187例符合研究标准的慢性肾小球肾炎患者按照随机数字表法分成2组,对照组采用口服氯沙坦钾片治疗,观察组联合中药活血化瘀治疗,治疗前后采用白细胞介素-1(interleukin1,IL-1)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-13(interleukin 13,IL-13)、血清肌酐(serum creatinine,SCr)、血尿素氮(blood urea nitrogen,BUN)、24h尿蛋白定量(24hurinary protein quantitation,24hUPro)及高敏C反应蛋白(hyper sensitive-C reactive protein,hsCRP)作为分析指标,比较两组患者临床疗效。结果两组患者治疗后IL-1、TNF-α、IL-13、SCr、BUN、24hUPro及hsCRP含量与治疗前比较,差异均有统计学意义(P<0.05)。两组患者治疗前后IL-1、TNF-α、IL-13、SCr、BUN、24hUPro及hsCRP差值比较,差异均有统计学意义(P<0.05)。两组临床疗效的分布比较,差异有统计学意义(P<0.05)。结论中西医结合治疗慢性肾小球肾炎的临床疗效显著。Objective To investigate the clinical effect of Huoxue Huayu Prescription combined with conventional Western medicine intervention in the treatment of chronic glomerulonephritis, and to provide a basis for integrated traditional Chinese and Western medicine therapy for chronic glomerulonephritis in clinical practice. Methods A total of 187 patients with chronic glomerulonephritis who met the inclusion criteria were divided into control group and observation group using a random number table. The patients in the control group were given oral losartan potassium tablets, and those in the observation group were given the traditional Chinese medicine Huoxue Huayu Prescription in addition to losartan potassium tablets. Interleukin-1（IL-1）, tumor necrosis factor-α（TNF-α）, interleukin-13（IL-13）, serum creatinine（SCr）, blood urea nitrogen（BUN）, 24-hour urinary protein quantitation（24hUPro）, and hypersensitive C-reactive protein （hsCRP） were measured before and after treatment, and the clinical outcome was compared between the two groups. Results Both groups had significant changes in IL-1, TNF-α, IL-13, SCr, BUN, 24hUPro, and hsCRP after treatment （P〈0.05）, and there were significant differences between the two groups in IL-1, TNF-α, IL-13, SCr, BUN, 24hUPro, and hsCRP before and after treatment （P〈0.05）. There was a significant difference in the distribution of clinical outcomes between the two groups （P〈0.05）. Conclusion Integrated traditional Chinese and Western medicine therapy has a marked clinical effect in the treatment of chronic glomerulonephritis.

关 键 词：慢性肾小球肾炎 活血化瘀 氯沙坦钾片 凝血功能 

分 类 号：R692.31[医药卫生—泌尿科学]