中性粒细胞胞外诱捕网与运动免疫  

NETs and Sports Immune

作　　者：石月[1,2] 杨翼[3] SHI Yue YANG Yia(Sport Dept. , Shanghai Sports Vocational Inst. , Shanghai 200232, China Sports Science Dept. , Shanghai Inst. of Physical Education, Shanghai 200438, China Health Science Dept. , Wuhan Sports Univ. , Wuhan 430029, China)

机构地区：[1]上海体育职业学院体育系,上海200237 [2]上海体育学院运动科学学院,上海200438 [3]武汉体育学院健康科学学院,湖北武汉430079

出　　处：《体育成人教育学刊》2017年第3期76-80,共5页Journal of Sports Adult Education

基　　金：2016上海市教育委员会和上海市教育发展基金会"晨光计划"资助项目(169CGB29)

摘　　要：中性粒细胞胞外诱捕网(Neutrophil extracellular traps,NETs)作为中性粒细胞实施免疫应答新的方式,通过自身网状结构和抗菌成分高效杀灭病原体微生物,拓展了中性粒细胞原有的吞噬和脱粒途径;NETs的过多形成会造成宿主细胞损伤,引发自身免疫性疾病及促进血栓的形成。力竭运动引起NETs的形成,并与血浆游离DNA及血液高凝关系密切。总结了NETs的成分、释放机制、诱因、信号通路,并对中性粒细胞及其胞外诱捕网在运动免疫领域的最新研究进展进行了概述。As a new netrophil immune response, NETs expand the neutrophil phagocytosis and the original threshing way through killing kill pathogenic microorganisms with its network structure and antibacterial ingredients; excessive NETs formation will cause the host cell damage, cause autoimmune disease and promote thrombosis. Exhaustive exercise induced the formation of NETs, and it has close relationship with plasma DNA and blood coagulation. The paper summerizes the components of NETs, release mechanism, incentive signal road, the latest research progress in the field and the movement of immune neutrophils and their extracellular traps.

关 键 词：运动人体科学 中性粒细胞胞外诱捕网 NETS 中性粒细胞 运动免疫 自身免疫疾病 

分 类 号：G804.2[文化科学—运动人体科学]