铑催化烯基氮杂环丙烷与炔胺的立体专一性[3+2]环加成反应  

Rhodium(I)-Catalyzed Stereospecific [3+2] Cycloadditions of Vinylaziridines and Ynamides

作　　者：朱超泽 冯见君[1] 张俊良[1] 

机构地区：[1]华东师范大学化学与分子工程学院,上海200062

出　　处：《有机化学》2017年第5期1165-1172,共8页Chinese Journal of Organic Chemistry

基　　金：上海市扬帆计划(No.15YF1403600);国家自然科学基金(Nos.21602062;21373088;21425205)资助项目~~

摘　　要：首次实现了铑催化的烯基氮杂环丙烷与炔胺底物的立体专一性的分子间[3+2]环加成反应.该反应具有较好的底物兼容性,反应条件温和,操作简便.此外,烯基氮杂环丙烷原料的手性可完全转移至环加成产物中,这为原子经济性且对映选择性地合成重要的2-氨基吡咯啉类衍生物提供了新的策略.The first rhodium-catalyzed stereospecific intermolecular [3＋2] cycloaddition reaction of vinylaziridines with ynamides was realized. The salient features of the transformation include broad substrate scope, mild reaction condition, and simple operation. Moreover, the chiratity of vinylaziridines can be completely transferred to the cycloadducts, representing an atom-economic and enantiospecific protocol for the construction of valuable 2-amino pyrroline derivatives.

关 键 词：过渡金属催化 环加成反应 烯基氮杂环丙烷 炔胺 含氮杂环 

分 类 号：O621.251[理学—有机化学]