季铵盐作为胺源经由两次C—N键活化的酯的胺解反应（英文）  

Aminolysis of Esters Using Quaternary Ammonium Salts as Amine Sources via Twice C—N Bond Activations

作　　者：王丽丽[1] 李鹏帅 贾美林[1] 包永胜[1] 

机构地区：[1]内蒙古师范大学化学与环境科学学院内蒙古绿色催化重点实验室,呼和浩特010022

出　　处：《有机化学》2017年第5期1220-1230,共11页Chinese Journal of Organic Chemistry

基　　金：supported by the National Natural Science Foundation of China(No.21462031);the Initial Special Research for National Basic Research Program of China(No.2014CB460609);the Research Program of Science and Technology at University of Inner Mongolia Autonomous Region(No.NJZZ14032)~~

摘　　要：报道了一种负载钯纳米颗粒催化多种芳基酯与季铵盐经由两次C—N键活化的,选择性合成酰胺的胺解反应.在这个反应中,Pd/γ-Al_2O_3催化剂表现出卓越的催化活性和空气中至少五次循环的重复利用性.试验结果表明季铵盐的第一次C—N键断裂得到卤代烷和三级胺,第二次C—N键断裂是通过产生亚胺离子中间体完成的.Catalyzed by supported palladium nanoparticles, an aminolysis reaction between various aryl esters and quaternary ammonium salts via twice C--N bond activations has been developed for selectively synthesis of amides. The Pd/）,-A1203 cat- alyst exhibited an excellent catalytic activity and reusability of at least five recycles in air for the reaction. The experiment results indicated that the first C--N cleavage of quaternary ammonium salt affords the tertiary amine and halohydrocarbon, and the second C--N cleavage proceeds via the formation of an iminium intermediate.

关 键 词：季铵盐 胺解 钯 C—N活化 芳基酯 

分 类 号：O621.25[理学—有机化学]