CeCl_3·7H_2O催化Groebke-Blackburn-Bienayme反应简便合成咪唑稠杂环化合物（英文）  

Convenient Synthesis of Imidazo-Fused Heterocycles via CeCl_3·7H_2O Catalyzed Groebke-Blackburn-Bienayme Reaction

作　　者：张钊瑞[1] 徐良[1] 唐汉秦 吴伯鑫 冯迪[1] 郭长彬[1] 

机构地区：[1]首都师范大学化学系,北京100048

出　　处：《有机化学》2017年第5期1252-1257,共6页Chinese Journal of Organic Chemistry

基　　金：supported by the National Natural Science Foundation of China(No.30873140);the Program for Excellent Talents of Beijing City(No.20071D0501600227);the Beijing Municipal Commission of Education(No.KM201010028011)~~

摘　　要：发展了由CeCl_3·7H_2O催化"一锅法"Groebke-Blackburn-Bienayme(GBB)反应合成咪唑稠杂环化合物的一种简单、高效和环境友好的合成方法.该反应以醛、氨基吖嗪、异腈三组分为原料,CeCl_3·7H_2O为催化剂,乙醇作为反应介质、60℃反应温度下可高收率合成相应咪唑稠杂环化合物.该方法具有底物范围广,反应时间短,纯化方法简单的优势.通过CeCl_3·7H_2O和高效催化剂LaCl_3·7H_2O的对比研究发现,CeCl3·7H_2O具有同样高的催化效率,为咪唑稠杂环化合物的合成提供了一种新的便利方法.A simple, efficient and eco-friendly ＂one-pot＂ method for the convenient synthesis of imidazo-fused heterocycles has been developed. The reaction was catalyzed by CeC13o7H20 in ethanol under 60 ℃ via Groebke-Blackburn-Bienayme （GBB） reaction of aldehydes, aminoazines and isocyanides. This method has many advantages of a wide range of substrates, short reaction time and easy purification. In addition, we conducted a comparative study of CeCl_3·7H2Owith CeCl_3·7H2O on their catalytic effect under the same reaction conditions, and found that CeCl_3·7H2O was comparable to CeCl_3·7H2O as catalyst in GBB reaction.

关 键 词：Groebke-Blackburn-Bienayme反应 咪唑稠杂环 CeCl3·7H2O LaCl3·7H2O 

分 类 号：O626[理学—有机化学]