手性多齿胺膦配体/铁簇合物催化酮的不对称转移氢化反应  

Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Chiral Multidentate Aminophosphine Ligands/Iron Cluster

作　　者：吴访[1] 张文景[1] 安冬丽[1] 李岩云[1] 高景星[1] 

机构地区：[1]厦门大学化学化工学院醇醚酯化工清洁生产国家工程实验室,厦门361005

出　　处：《有机化学》2017年第5期1295-1299,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21173176;21673190);中央高校基本科研业务费专项资金(No.20720150040)资助项目~~

摘　　要：从廉价易得、绿色环保的铁簇合物Fe_3(CO)_(12)出发,开展了其与手性多齿胺膦配体(R,R,R,R)-PN_4H_6原位生成的催化体系在酮的不对称转移氢化中的应用研究.通过考察温度、添加剂等影响因素,探索最优的反应条件,并将其进一步应用于多种芳香酮的不对称转移氢化反应,得到高达96%ee的对映选择性.As one of the most abundant metals on earth, iron is cheap and low toxicity. Herein we reported the asymmetric transfer hydrogenation of （ATH） ketones catalyzed by the system generated in situ from chiral multidentate aminophosphine ligand （R,R,R,R）-PN4H6 and Fe3（CO）12. The effects of temperature and additive on the ATH of propiophenone were examined. After optimizing the reaction conditions, we applied the catalytic system to the ATH of various aromatic ketones, obtaining the corresponding optical active alcohols with high enantioselectivities （up to 96% ee）.

关 键 词：手性胺膦配体 铁簇合物 廉价金属 酮 不对称转移氢化反应 

分 类 号：O621.251[理学—有机化学]