腰椎间盘突出物中IL-8、IL-10表达与神经根性疼痛相关性分析  

Expression level of IL-8,IL-10 in lumbar protrusion and its correlation with nerve root pain

作　　者：林磊[1] 李般若 王青平[1] 李锋涛[2] 吴伟[1] 冉明全 邱龙顺 

机构地区：[1]汉中市中心医院脊柱二病区,陕西汉中723000 [2]西安交通大学第二附属医院骨二科,陕西西安710004

出　　处：《临床军医杂志》2017年第5期514-516,共3页Clinical Journal of Medical Officers

基　　金：陕西省自然科学基金(2016JM8010)

摘　　要：目的探讨腰椎间盘突出物中白介素-8(IL-8)、白细胞介素-10(IL-10)的表达水平,并分析其与神经根性疼痛的相关性。方法选取汉中市中心医院自2014年9月至2016年12月收治的腰椎间盘突出症患者78例,并根据腰椎间盘突出程度分为观察A组(隆起型)、观察B组(突出型)、观察C组(游离型);另选取同时期在我院行腰椎骨折手术的患者18例为对照组。检测4组腰椎间盘组织中IL-8及IL-10的表达水平,并分析其与神经根性疼痛的相关性。结果与对照组比较,观察A组、观察B组及观察C组患者的IL-8及IL-10水平均明显升高(P<0.05);而且,随着腰椎间盘突出程度的加重,IL-8及IL-10水平随之增高(P<0.05)。观察组不同髓核突出程度患者之间神经根疼痛程度视觉模拟评分(VAS)比较,差异均无统计学意义(P>0.05);腰椎间盘突出物中IL-8及IL-10的表达均与神经根疼痛VAS评分呈正相关关系。结论腰椎间盘突出物中IL-8及IL-10的表达水平较正常人高,且随着腰椎间盘突出程度的加重,IL-8及IL-10水平随之增高,与神经根性疼痛存在一定的相关性。Objective To investigate the expression level of interleukin 8（[L-8） and interleukin-10（IL-10） in lumbar protrustion, and analyze its correlation with nerve root pain. Methods A retrospective study was performed on 78 cases of patients with lumbar disc prolapse who were admitted from September 2014 to December 2016. According to the degree of lumbar disc, patients were divided into the observation group A （uplift type）, the observation group B （outstanding type）, and observation group C （free type ） ;at the same time,another 18 cases who underwent lumbar fracture surgery were in the control group. The expression level of IL-8 and IL-10 in lum- bar protrusion was detected and the its correlation with nerve root pain was analyzed. Results Compared with the control group, the expression level of IL-$ and IL-10 in the observation group A to C was significantly higher（ P 〈 0. 05 ） ;furthermore, the expression lev- el of IL-8 and IL-10 increased with the degree of lumbar disc aggravated（ P 〈 0. 05 ）. There was no significant difference in patients of observation groups with different degrees of herniated and nerve root pain VAS score （P 〉 0.05 ） ; expression level of IL-8 and IL-10 was positively correlated with nerve root pain VAS score. Conclusion The expression level of IL-8 and IL-10 in lumbar protrusion is hi^her than that of normal.it increases with the demree of lumbar disc aggravates,and has a certain correlation with nerve root pain.

关 键 词：炎症因子 腰椎间盘突出症 神经根性疼痛 相关性 

分 类 号：R681.53[医药卫生—骨科学]