基于神经胶质细胞的癌性疼痛机制及相关药物研究进展  

Mechanisms and Related Drugs of Glia in Regulating Cancer Pain

作　　者：胡雅慧 李运曼[1] 

机构地区：[1]中国药科大学天然药物活性组分与药效国家重点实验室基础医学与临床药学学院生理教研室,南京210009

出　　处：《药学与临床研究》2017年第3期232-236,共5页Pharmaceutical and Clinical Research

基　　金：国家科技十二五重大专项"重大新药创制"(临床前研究项目)基金资助课题(2012ZX09J12110-06B)

摘　　要：导致癌痛的机制十分复杂,中枢神经系统的小胶质细胞和星形胶质细胞在癌痛的发生发展中起着重要的作用。活化的胶质细胞通过上调胶质标记物,激活细胞内的信号通路,上调胶质细胞受体和化学通道,下调转运蛋白,释放炎性介质参与癌痛的调节。作用于胶质细胞减轻癌痛的药物包括丙戊茶碱、二甲胺四环素、D-型氨基酸氧化酶抑制剂、脂氧素和中药提取物等。本文对胶质细胞参与癌痛调节机制及相关药物的研究进展作一综述。The mechanism of cancer pain is complex. Astrocytes and microglia from central nervous system play essential roles in the development of cancer pain. Activation of glial cells would increase the expression of glial markers, activate the intracellular signaling pathways, upregulate the expression of chemokine receptors, downregulate the glutamate transporters and release inflammatory mediators. The glial cells related drugs for cancer pain relief include propentofylline, minocycline, D-Amino acid oxidase inhibitor, lipoxin and extracts of traditional Chinese medicine. This review aims to state the mechanisms of glial cells in cancer pain and the research development of related drugs.

关 键 词：小胶质细胞 星形胶质细胞 癌痛 胶质细胞相关药物 

分 类 号：R979.1[医药卫生—药品] R971.1[医药卫生—药学]