高敏C反应蛋白与高血压患者肾功能损伤的相关性研究  

Association between serum hs-CRP level and renal function impairment in hypertensive patients

作　　者：师树田[1] 李艳芳[1] 艾辉[1] 阙斌[1] 王春梅[1] 聂绍平[1] SHI Shu-tian LI Yan-fang AI Hui et al(Emergency ＆ Critical Care Center ,Affiliated Beijing Anzhen Hospital of Capital Medical University,Beijing 100029, China)

机构地区：[1]首都医科大学附属北京安贞医院急诊危重症中心,100029

出　　处：《中华老年心脑血管病杂志》2017年第6期577-579,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：北京市科技计划(Z141107002514014);北京市医院管理局重点医学专业发展计划(ZYLX201710)

摘　　要：目的探讨高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)与高血压患者肾功能损伤是否具有直接相关性。方法收集2016年1~6月就诊于北京安贞医院的高血压患者496例,按照估算的肾小球滤过率(estimated glomerular filtration rate,eGFR)分为肾功能正常组411例和肾功能降低组85例。记录患者身高、体质量、血压。采集外周静脉血5ml,由中心化验室统一检测尿素、肌酐、TC、TG、HDL-C、LDL-C、hs-CRP。结果 2组女性、冠心病、糖尿病、吸烟、体质量指数、TC、TG、HDL-C及LDL-C比较,差异无统计学意义(P>0.05)。肾功能降低组年龄、高血压病程、尿素、肌酐、hs-CRP明显高于肾功能正常组[(62.44±17.81)岁vs(60.49±14.40)岁,P=0.014;(7.30±5.90)年vs(6.10±4.70)年,P=0.021;(6.53±1.88)mmol/L vs(4.21±1.60)mmol/L,P=0.000;(137.50±42.48)μmol/L vs(78.67±21.71)μmol/L,P=0.000;(4.63±2.41)mg/L vs(2.04±1.41)mg/L,P=0.000]。相关分析显示,eGFR与年龄、高血压病程、尿素、肌酐呈负相关(r=-0.451,r=-0.564,r=-0.545,r=-0.794,P=0.000)。结论 hs-CRP水平在高血压合并肾功能损伤的患者升高。Objective To study the association between serum hs-CRP level and renal function impairment in hypertensive patients. Methods Four hundred and ninety-six hypertensive patients admitted to our hospital from January 2016 to June 2016 were divided into normal renal function group （n=411） and impaired renal function group （n=85） according to their eGFR. Their body height,BMI,blood pressure and serum levels of BUN,Scr,LDL-C, HDL-C,TC,TG,hs-CRP were measured. Results No significant difference was found in gender, prevalence of CHD and DM, smoking history, BMI, and serum levels of TC, TG, HDL-C, LDL-C between the two groups （P〉0.05）. The age was significantly older, the duration of hypertension was significantly longer, the serum levels of BUN,Scr and hs-CRP were significantly higher in impaired renal function group than in normal renal function group （62.44 ± 17. 81 years vs 60.49± 14. 40 years, P = 0. 014; 7.30±5.90 years vs 6.10±4.70 years,P=0. 021;6. 53±1. 88 mmol/L vs 4.21±1.60 mmol/L, P=0. 000;137. 50±42.48 μmol/L vs 78. 67±21. 71μmol/L, P= 0. 00074. 63±2.41 mg/L vs 2.04±1.41 rag/L, P = 0. 000）. Correlation analysis showed that eGFR was negatively associated with age,duration of hypertension,serum levels of BUN and Scr （r=-0. 451,r=-0. 564,r=- 0. 545,r=-0. 794, P〈0.01）. Conclusion Serum hs-CRP level is higher in hypertensive patients with renal function impairment.

关 键 词：C反应蛋白质 高血压 肾功能不全 肾小球滤过率 

分 类 号：R544.1[医药卫生—心血管疾病] R692[医药卫生—内科学]