血小板与淋巴细胞比值与NSTEMI患者冠状动脉病变严重程度的相关性研究  

Correlation between platelet and lymphocyte ratio and severity of coronary artery lesions in patients with non-ST-segment elevation myocardial infarction

作　　者：郭英杰[1] 宁彬[1] 葛慧娟[1] 庄晓赛[1] 

机构地区：[1]阜阳市人民医院心血管内科,阜阳236001

出　　处：《中国循证心血管医学杂志》2017年第5期600-602,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的研究血小板与淋巴细胞比值(PLR)与非ST段抬高型心肌梗死(NSIEMI)患者冠状动脉病变程度的关系。方法选取2013年2月~2015年12月于阜阳市人民医院心血管内科住院的NSTEMI患者共92例,行冠状动脉造影检查并予SYNTAX评分系统评分,取同期该院临床怀疑冠心病而冠状动脉造影结果正常的非冠心病者82例作为对照组。所有患者检测外周静脉血小板计数及淋巴细胞计数,并计算PLR。比较各组患者PLR水平,分析其与冠状动脉病变严重程度SYNTAX评分的相关性。结果对照组PLR显著低于NSTEMI组,差异有统计学意义(P<0.01)。PLR与SYNTAX评分呈显著正相关(r=0.522,P<0.01)。Logistic回归分析显示PLR是NSTEMI患者冠状动脉病变高SYNTAX评分的独立预测因子(OR=1.018,95%CI:1.006~1.029,P<0.01)。结论非ST段抬高型心肌梗死患者PLR水平显著升高,PLR与冠状动脉病变严重程度相关,可作为NSTEMI患者冠状动脉病变的简单预测方法。Objective To study the correlation between platelet and lymphocyte ratio （PLR） and severity of coronary artery lesions in patients with non-ST-segment elevation myocardial infarction （NSTEMI）. Methods NSTEMI patients （n=92） were chosen as NSTEMI group from the Department of Cardiovascular Diseases of People’s Hospital of Fuyang City from Feb. 2013 to Dec. 2015, and given examination of coronary angiography （CAG） and the results were graded by using SYNTAX scoring system. At the same time, the patients with suspected coronary heart disease and normal CAG results （n=82） were chosen as control group. The counts of peripheral venous platelet and lymphocytes were detected and PLR was calculated in all patients. The level of PLR was compared between 2 groups, and correlation between PLR and SYNTAX scores of severity of coronary artery lesion was analyzed. Results The level of PLR was significantly lower in control group than that in NSTEMI group （P〈0.01）, and PLR was positively correlated to SYNTAX scores （r=0.522, P〈0.01）. Logistic regression analysis showed that PLR was an independent predictive factor for higher SYNTAX scores of coronary artery lesions in NSTEMI patients （OR=1.018, 95%CI： 1.006-1.029, P〈0.01）. Conclusion The level of PLR increases significantly, and PLR is correlated to the severity of coronary artery lesions in NSTEMI patients, which can be taken as a simple method for predicting coronary artery lesions.

关 键 词：血小板 淋巴细胞 心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]