甲状腺乳头状癌合并桥本氏甲状腺炎的BRAF基因表达及侵袭性  

Expression and Invasion of BRAF Gene in Thyroid Papillary Carcinoma with Hashimoto's Thyroiditis

作　　者：彭莉娜[1] 李征毅[2] 任光辉[1] 邰沁文[1] 高峰[1] 张金辉[1] PENG Li-na LI Zheng-yi REN Guang-hui et al(Shenzhen Hospital of Southern Medical University, Shenzhen 518000, China)

机构地区：[1]南方医科大学深圳医院,广东深圳518000 [2]广东省深圳市第二人民医院

出　　处：《中国医学创新》2017年第16期5-8,共4页Medical Innovation of China

基　　金：深圳市宝安区社会公益项目(2016CX312)

摘　　要：目的:探讨甲状腺乳头状癌合并桥本氏甲状腺炎患者的BRAF基因表达特点以及侵袭性。方法:将86例甲状腺乳头状癌患者依据是否合并桥本氏甲状腺炎分为对照组和观察组,统计两组病理学特征、BRAF基因表达和侵袭性检测结果,并进行比较。结果:两组性别、年龄、甲状腺弥漫性肿大和血清自身免疫抗体水平相比,差异均有统计学意义(P<0.05)。观察组BRAF基因突变率、甲状腺外侵犯率和淋巴结转移率明显低于对照组(P<0.05);BRAF基因表达呈阳性的患者更容易发生甲状腺外侵犯和淋巴结转移(P<0.05)。结论:桥本氏甲状腺炎可以对甲状腺乳头状癌侵袭性有一定限制作用。Objective： To investigate the expression characteristics and invasiveness of BRAF gene in patients with papillary thyroid carcinoma complicated with Hashimoto＇s thyroiditis.Method： A total of 86 patients with papillary thyroid carcinoma were divided into the control group and the observation group according to whether or not combined Hashimoto＇s thyroiditis, 43 cases in each group.The histopathological features, BRAF gene expression and invasive test results of two groups were compared.Result： There were statistical significance in the gender, age, thyroid diffuse enlargement and serum autoimmune antibody level of two groups （ P〈0.05 ） . The BRAF gene mutation rate, thyroid invasion rate and lymph node metastasis rate of the observation group were significantly lower than those of the control group （ P〈0.05 ） .The patients with BRAF gene expression were more likely to develop thyroid invasion and lymph node metastasis （P〈0.05） .Conclusion： Hashimoto＇s thyroiditis can have a certain limit on the invasiveness of thyroid papillary carcinoma.

关 键 词：甲状腺乳头状癌 桥本氏甲状腺炎 BRAF基因表达 侵袭性 

分 类 号：R581.3[医药卫生—内分泌] R736.1[医药卫生—内科学]