腺苷蛋氨酸对慢性乙型肝炎患者蛋白代谢及纤维化指标的影响观察  

Observation on the influence of ademetionine for the proteometabolism and fibrosis indexes of patients with chronic hepatitis B

作　　者：陈毅芳[1] 何兰香[1] 裘琳琳[1] 

机构地区：[1]余杭区第一人民医院药剂科

出　　处：《中国生化药物杂志》2017年第5期58-60,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的观察腺苷蛋氨酸对慢性乙型肝炎患者蛋白代谢及纤维化指标的影响。方法将2016年1~12月余杭区第一人民医院收治的110例慢性乙肝患者随机分为对照组（常规乙肝治疗组）55例和观察组（常规治疗加腺苷蛋氨酸组）55例。检测与比较2组患者治疗前和治疗后的蛋白代谢指标及纤维化指标血清表达水平。结果治疗前2组患者的蛋白代谢指标及纤维化指标血清表达水平比较,差异均无统计学意义,而治疗后观察组的蛋白代谢指标血清表达水平均高于对照组,纤维化指标血清表达水平均低于对照组,差异均有统计学意义（P均〈0.05）。结论腺苷蛋氨酸可显著地改善慢性乙型肝炎患者的蛋白代谢及纤维化指标的表达状态,故腺苷蛋氨酸在慢性乙型肝炎患者中的应用价值相对更高。Objective To observe the influence of ademetionine for the proteometabolism and fibrosis indexes of patients with chronic hepatitis B.Methods110 patients with chronic hepatitis B in our hospital from January to December 2016 were randomly divided into control group（conventional treatment of hepatitis B group）55 cases and observation group（conventional treatment and ademetionine group）55 cases.The serum expression levels of proteometabolism and fibrosis indexes of two groups before the treatment and after the treatment were detected and compared.ResultsThe serum expression levels of proteometabolism and fibrosis indexes of two groups before the treatment were compared,there were no significant differences,while the serum expression levels of proteometabolism indexes of observation group after the treatment were all higher than those of control group,the serum expression levels of fibrosis indexes were all lower than those of control group,there were all significant differences（all P〈0.05）.ConclusionThe ademetionine can significantly improve the expression state of proteometabolism and fibrosis indexes of patients with chronic hepatitis B,so the application value for the patients with chronic hepatitis B is relatively higher.

关 键 词：腺苷蛋氨酸 慢性乙型肝炎 蛋白代谢指标 纤维化指标 

分 类 号：R512.62[医药卫生—内科学]