冠心病患者同型半胱氨酸水平特点及叶酸对其的干预效果  

Characteristics of homocysteine in patients with Coronary Heart Disease and the effect of folic acid on its intervention

作　　者：张立建[1] 李慧敏[1] 潘锦汉[1] 余市成 

机构地区：[1]广州医科大学附属第三医院荔湾医院心内科

出　　处：《中国生化药物杂志》2017年第5期61-62,65,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨冠心病患者同型半胱氨酸水平特点及叶酸对其的干预效果。方法选取2015年12月~2016年12月广州医科大学附属第三医院荔湾医院心内科收治的90例冠心病患者作为研究组,随机分为A组和B组,每组45例,A组接受常规治疗,B组在常规治疗基础上加用叶酸。另选取同期前来本院体检的90例健康人群作为对照组。记录研究组和对照组血浆同型半胱氨酸水平检测结果,A组、B组治疗前后血浆同型半胱氨酸水平检测结果及心绞痛状态（发病频率、持续时间）变化情况。结果研究组治疗前血浆同型半胱氨酸水平显著高于对照组（P〈0.05）;治疗后A组和B组的同型半胱氨酸水平均下降,且B组低于A组,组间差异有统计学意义（P〈0.05）;治疗后A组和B组心绞痛发作持续时间、频率均较之前显著减少,B组心绞痛发作情况改善效果更为理想（P〈0.05）。结论血浆同型半胱氨酸水平检测结果可作为临床诊断冠心病并判断其疗效的重要依据,在常规治疗基础上加用叶酸有利于提高冠心病患者治疗效果。Objective To investigate the characteristics of homocysteine in patients with coronary heart disease （CHD） and the intervention effect of folic acid.Methods90 patients with coronary heart disease form internal medicine-cardiovascular department in the third affiliated Liwan hospital of Guangzhou Medical University from December 2015 to December 2016 as the study group.They were randomly divided into group A and group B, 45 patients in each group.The group A received routine treatment and Group B on the basis of conventional treatment plus folic acid.Another 90 healthy people who came to our hospital during the same period were selected as control group.The plasma homocysteine level of study group and control group were compared and plasma homocysteine level and angina status（frequency and duration of disease） of A and B group were compared before and after treatment.ResultsThe plasma homocysteine level of study group was significantly higher than that of the control group （P〈0.05）.After treatment, plasma homocysteine level,frequency and duration of disease of two groups were better than that of before treatment and B group was lower than that of A group（P〈0.05）.ConclusionThe results of plasma homocysteine levels can be used as an important basis for the clinical diagnosis of coronary heart disease and to determine its efficacy.

关 键 词：叶酸 冠心病 同型半胱氨酸 应用效果 

分 类 号：R541.4[医药卫生—心血管疾病]