左西孟旦对急性失代偿性心力衰竭全部窦性心搏RR间期的标准差、RR间期平均值标准差值的影响及其临床治疗效果分析  

Effect of levosimendan on SDNN and SDANN changes in patients with acute decompensated heart failure and its clinical efficacy and safety

作　　者：李明英 丁云 吴燕飞 夏靓 

机构地区：[1]浙江绿城心血管病医院药剂科

出　　处：《中国生化药物杂志》2017年第5期246-248,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨左西孟旦对急性失代偿性心力衰竭患者的治疗效果及对患者全部窦性心搏RR间期的标准差（standard diviation of NN intervals,SDNN）、RR间期平均值标准差（standard diviation average of NN intervals,SDANN）值的影响。方法回顾性分析2014年1月~2016年8月在浙江绿城心血管病医院接受治疗的120例急性失代偿性心力衰竭患者的临床资料,根据其治疗方式分为对照组和观察组,其中对照组49例,观察组71例。对照组给予常规药物治疗,观察组在对照组的基础上给予左西孟旦治疗。观察2组患者的治疗效果,比较2组患者治疗前后心功能、SDNN、SDANN值和不良反应发生率的差别。结果治疗后,观察组治疗的有效率为98.59%,明显高于对照组;观察组的LAD、RAD、LVESD、LVEDD和BNP低于对照组,LVEF水平高于对照组,差异有统计学意义（P〈0.05）;观察组的SDNN、SDANN、RMSSD和PNN50（%）水平均高于对照组,差异有统计学意义（P〈0.05）。结论左西孟旦对急性失代偿性心力衰竭有较好的治疗效果,可明显改善患者的SDNN、SDANN水平,且不良反应发生率低。Objective To investigate the therapeutic effect of levosimendan on acute decompensated heart failure and its effect on SDNN and SDANN values.MethodsThe clinical data of patients with acute decompensated heart failure treated in Zhejiang Greentown Cardiovascular Hospital from January 2014 to August 2016 were retrospectively analyzed.According to their treatment methods, they were divided into control group and observation group.There were 49 cases in the control group and 71 cases in the observation group.The control group was given conventional drug treatment, the observation group was given levosimendan treatment on the basis of the control group.The therapeutic effects of the two groups were observed.The difference of cardiac function, SDNN, SDANN value and adverse reaction between the two groups were compared before and after treatment.ResultsAfter treatment, the observation group efficiency was 98.59%, significantly higher than the control group;the observation group LAD, RAD, LVESD, LVEDD and BNP lower than the control group, the level of LVEF was higher than the control group, the difference was statistically significant （P〈0.05）;the observation group SDNN, SDANN, RMSSD and PNN50 （%） was higher than that of the control group, the difference was statistically significant （P〈0.05）.ConclusionLevosimendan has good therapeutic effect on acute decompensated heart failure, can significantly improve the level of SDNN, SDANN, and the incidence of adverse reactions is low.

关 键 词：左西孟旦 心力衰竭 心率变异性 心功能 

分 类 号：R541[医药卫生—心血管疾病]