酒石酸美托洛尔静脉滴注联合口服对急性前壁心肌梗死患者左心室功能和不良心血管事件的影响  

Influence of intravenous injection combined with oral of metoprolol tartrate on left ventricular function and adverse cardiovascular events of patients with acute anterior myocardial infarction

作　　者：陈莹[1] 王晓霞 王瑾[1] 张瑛琪[1] 韩彩莉 游道锋[1] 

机构地区：[1]河北医科大学第一医院急诊科,河北石家庄050031 [2]秦皇岛紫竹药业有限公司质量检验科,河北秦皇岛066004

出　　处：《中国生化药物杂志》2017年第5期249-251,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：河北省科技计划项目(152777203,ORCID ID:0000-0001-8490-5672)

摘　　要：目的观察酒石酸美托洛尔静脉滴注联合口服对急性前壁心肌梗死患者左心室功能和不良心血管事件的影响。方法选取河北医科大学第一医院收治的急性前壁心肌梗死患者84例作为研究对象,按照给药方式分为静脉组和联合组各42例,其中静脉组给予静脉注射酒石酸美托洛尔治疗,联合组给予口服联合静脉注射酒石酸美托洛尔治疗。观察2组临床治疗效果、左心室功能、BP和HR水平以及不良心血管事件发生率。结果联合组总有效率95.24%显著高于静脉组80.95%（P〈0.05）;治疗后2组LVEF显著高于治疗前（P〈0.05）,且联合组显著高于静脉组（P〈0.05）,2组LVESD、LVEDD水平显著低于治疗前（P〈0.05）,且联合组显著低于静脉组（P〈0.05）;治疗后2组DBP、SBP、HR显著低于治疗前（P〈0.05）,且联合组显著低于静脉组（P〈0.05）;联合组不良心血管发生率为11.90%与静脉组16.67%比较差异无统计学意义（P〉0.05）。结论酒石酸美托洛尔静脉滴注联合口服可有效改善急性前壁心肌梗死患者左心室功能,降低不良心血管事件发生率。Objective To explore the influence of intravenous injection combined with oral of metoprolol tartrate on left ventricular function and adverse cardiovascular events of patients with acute anterior myocardial infarction.Methods84 cases of Patients with acute anterior myocardial infarction treated in the First Hospital of Hebei Medical University were selected as the study objects, and were divided into vein group and combination group according to drugs-taking modes, 42 cases in each groups.The vein group were treated with intravenous injection of metoprolol tartrate, and the combination group were treated with intravenous injection combined with oral of metoprolol tartrate.Clinical effect, left ventricular function, BP and HR levels, and incidence of adverse cardiovascular events were observed in the two groups.ResultsThe total effective rate of the combination group was 95.24% significantly higher than that of 80.95% in the vein group（P〈0.05）.After treatment, LVEF was significantly higher than that before treatment in the two groups （P〈0.05）, which of the combination group was significantly higher than that of the vein group （P〈0.05）.The levels of LVESD and LVEDD were significantly lower than those before treatment in the two groups （P〈0.05）, which of the combination group were significantly lower than those in the vein group（P〈0.05）.After treatment, DBP, SBP and HR were significantly lower than those before treatment in the two groups （P〈0.05）, which of the combination group were significantly lower than those in the vein group（P〈0.05）.The incidence of adverse cardiovascular disease was 11.90% in the combination group, and it was no significantly different from that of 16.67% in the vein group （P〉0.05）.ConclusionIntravenous injection combined with oral of metoprolol tartrate can effectively improve left ventricular function of patients with acute anterior myocardial infarction, and reduce incidence of adverse cardiovascular events.

关 键 词：酒石酸美托洛尔 急性前壁心肌梗死 左心室功能 不良心血管事件 

分 类 号：R972[医药卫生—药品] R541[医药卫生—药学]