阿托伐他汀对不稳定型心绞痛患者的疗效及心血管事件的影响  

Effect of atorvastatin on efficacy and cardiovascular events in patients with unstable angina pectoris

作　　者：章晨[1] 郑永 

机构地区：[1]金华市中心医院心内科,浙江金华321099 [2]兰溪市中医院急诊科,浙江兰溪321100

出　　处：《中国生化药物杂志》2017年第5期318-320,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨阿托伐他汀对不稳定型心绞痛患者的疗效及心血管事件的影响。方法选择2014年8月~2016年8月金华市中心医院住院治疗的UAP患者128例,128例UAP患者采用随机数字表法随机分为观察组和对照组,所有组患者均给予低盐低脂饮食。2组患者均予抗血小板聚集、降压、降脂等常规治疗,观察组在此基础上同时联合阿托伐他汀钙40 mg/d,口服,连用1个月。比较2组治疗后的总有效率、2组患者治疗前后的TC、TG及LDL-C、HDL-C水平,以及心血管事件发生率。结果观察组和对照组无一例发生心源性死亡,其中观察组心血管事件发生率9.38%,与对照组比较差异有统计学意义（P〈0.05）。观察组的TC、TC、LDL-C治疗后分别较治疗前及对照组改善更显著。观察组的临床疗效显著优于对照组,组间差异有统计学意义（P〈0.05）。结论阿托伐他汀能显著提高不稳定型心绞痛治疗的疗效,且降低血脂水平,减少了心血管事件的发生,改善预后。Objective To investigate the effect of atorvastatin on the curative effect and cardiovascular events in patients with unstable angina pectoris.Methods128 patients with UAP were enrolled in Jinhua Central Hospital from August 2014 to August 2016, and 128 patients with UAP were randomly divided into observation group and control group.All the patients were given low salt and low fat diet.Two groups of patients were anti-platelet aggregation, blood pressure, lipid-lowering and other conventional treatment, observation group on the basis of simultaneous atorvastatin calcium 40mg/d, oral, once every month.The levels of TC, TG and LDL-C, HDL-C and the incidence of cardiovascular events were compared between the two groups before and after treatment.ResultsThere was no case of cardiac death in the observation group and the control group.The incidence of cardiovascular events in the observation group was 9.38%, which was significantly different from that in the control group （P〈0.05）.The levels of TC, TC and LDL-C in the observation group were significantly higher than those before treatment and control group, respectively.The clinical effect of the observation group was significantly better than that of the control group, the difference was significant （P〈0.05）.ConclusionAtorvastatin can significantly improve the efficacy of unstable angina treatment, and reduce blood lipid levels, reducing the incidence of cardiovascular events, improve the prognosis.

关 键 词：不稳定型心绞痛 阿托伐他汀 心血管事件 血脂 

分 类 号：R541.4[医药卫生—心血管疾病]