米非司酮配合米索前列醇终止瘢痕子宫妊娠的疗效评价  

Efficacy of mifepristone combined with misoprostol in terminating scar uterine pregnancy

作　　者：王旭美[1] 黄可[2] 

机构地区：[1]江苏省南通市第一人民医院妇科,江苏南通226001 [2]南京医科大学,江苏南京210029

出　　处：《中国生化药物杂志》2017年第5期385-387,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的研究分析米非司酮配合米索前列醇终止瘢痕子宫妊娠的治疗效果评价以及安全性分析。方法选取南通市第一人民医院于2014年2月~2016年12月期间瘢痕子宫妊娠终止的产妇50例做本次研究过程中的实验组,选择无瘢痕子宫妊娠的产妇50作为本次研究过程中的对照组。实验组与对照组患者均进行米非司酮治疗,口服使用,患者在药物治疗的第3天实验组用米索前列醇进行用药,该药选取空腹用药,在阴道后穹窿上放置。比较分析实验组与对照组患者的治疗效果以及不良反应情况。结果经过一段时间治疗后,实验组与对照组的妊娠产物排出时间以及阴道出血量和宫缩发动时间比较差异无统计学意义。实验组50例患者中,治疗有效例数为47例,治疗有效率为94.0%。对照组50例患者中,治疗有效例数为41例,治疗有效率为82.0%。由此可得,实验组治疗有效率显著高于对照组,不具有统计学意义（P〈0.05）。实验组患者不良反应发生概率为6.0%,对照组不良反应发生率为14.0%。由此可得,实验组不良反应发生概率显著低于对照组,具有统计学意义（P〈0.05）。结论米非司酮配合米索前列醇治疗终止瘢痕子宫效果较好,治疗有效率较高,不良反应发生率降低,安全性较高,能够在很大程度上减少对患者造成的创伤,具有临床进一步推广和应用的意义。Objective To study the efficacy and safety of mifepristone combined with the end of pregnancy in the treatment of uterine scar pregnancy.Methods50 cases of the experimental group in our hospital from February 2014 to December 2016 during the termination of pregnancy uterine scar pregnancy in this study in the research process, no scar uterine pregnancy were 50 as the control group in the process of research.The experimental group and the control group patients were given mifepristone treatment, oral use, patients in the drug treatment of third days should be carried out taking the drug misoprostol experiment, fasting medication, placed in the posterior fornix of vagina.Comparative analysis of the experimental group and the control group of patients with treatment effects and adverse reactions.ResultsAfter a period of treatment, the experimental group and the control group, the time of vaginal discharge and the amount of vaginal bleeding and uterine contractions were no significant difference in the time, not statistically significant.The experimental group of 50 patients, the number of effective treatment for 47 cases, the effective rate was 94%.The control group of 50 patients, the number of effective treatment for the treatment of 48 cases, the effective rate was 96%.As a result, there was no significant difference between the experimental group and the control group in the treatment efficacy, which was not statistically significant （P〉0.05）.The incidence of adverse reactions in the experimental group was 10%, and the incidence of adverse reactions in the control group was 8%.As a result, there was no significant difference between the experimental group and the control group in the incidence of adverse reactions, which was not statistically significant.ConclusionMifepristone combined with carboprost suppository in the treatment of uterine scar end effect is good, high treatment efficiency, reduce the incidence of adverse reaction, high safety, can reduce the patients caused by trauma to a great extent, i

关 键 词：米非司酮 米索前列醇 瘢痕子宫妊娠 疗效 

分 类 号：R714.2[医药卫生—妇产科学]