肺癌并发抗利尿激素不适当分泌综合征2例报告及文献复习  

Lung cancer complicated with syndrome of inappropriate secretion of antidiuretic hormone:A report of 2 cases and literature review

作　　者：肖燕[1] 王欢[1] 王淑敏[1] 高影[1] XIAO Yan WANG Huan WANG Shumin GAO Ying(Department of Endocrinology and Metabolism, First Hospital, Jilin University, Changchun 130021, China)

机构地区：[1]吉林大学第一医院内分泌代谢科,吉林长春130021

出　　处：《吉林大学学报（医学版）》2017年第3期643-645,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅科研基金资助课题(20070929-02)

摘　　要：目的:分析2例肺癌并发抗利尿激素不适当分泌综合征(SIADH)患者的临床资料,提高对该病的临床认识和管理。方法:患者1单纯采用肺癌化学药物治疗,完成7个疗程化疗。患者2未行肺癌病因治疗,通过严格限制液体量摄入及口服托伐普坦治疗低钠血症。结果:伴随肺癌反复进展,患者1低钠血症及相关临床症状缓解欠佳。患者2口服托伐普坦3d后血钠水平恢复正常。结论:约1/3低钠血症患者出现SIADH,临床治疗中应给予针对低钠血症的病因治疗和对症治疗。Objective：To analyze the clinical materials of 2 patients with lung cancer complicated with syndrome of inappropriate secretion of antidiuretic hormone （SIADH）,and to improve the clinical awareness and management.Methods：One patient was treated with lung cancer chemotherapy alone for 7 courses.The other patient received the strictly limited for liquid intake and tolvaptan by oral against hyponatremia without chemotherapy.Results：With the relapsing and advancing of lung cancer,the hyponatremia and its relevant symptoms of the first patient were poorly relieved.While the level of serum sodium of the second patient returned to the normal level 3 d after administration of tolvaptan.Conclusion：About one-third of the patients with hyponatremia have SIADH.The etiological treatment and symptomatic therapy of hyponatremia should be given to the patients in clinical treatment.

关 键 词：抗利尿激素不适当分泌综合征 低钠血症 肺肿瘤 托伐普坦 

分 类 号：R589.4[医药卫生—内分泌]