某院120例AIDS患者不同HAART方案的药物不良反应分析  

Analysis of Adverse Reactions of Different HAART Regimens in 120 AIDS Patients in a Hospital

作　　者：李伟煊[1] 林昭平 雷露雯[1] 莫迪威 LI Weixuan LIN Zhaoping LEI Luwen MO Diwei(Nanhai Hospital of Southern Medical University, Foshan, Guangdong 528200, China FoShan University, Foshan , Guangdong 52800, China)

机构地区：[1]南方医科大学附属南海医院,广东佛山528200 [2]佛山科学技术学院,广东佛山528000

出　　处：《今日药学》2017年第5期341-344,共4页Pharmacy Today

摘　　要：目的回顾性分析某院艾滋病(AIDS)患者高效抗逆转录病毒治疗(HAART)过程中药物不良反应(ADR)发生的特点,为临床合理用药提供参考。方法将2014~2015年120例已确诊AIDS并接受HAART治疗的患者随机分为两组,分别为A组:拉米夫定+替诺福韦+依非韦伦(3TC+TDF+EFV);B组:齐多拉米双夫定+依非韦伦(AZT/3TC+EFV),根据Karch和Lasagna评定法对治疗过程中出现的ADR评定,并对ADR的类型、出现的时间及转归进行回顾性分析。结果 AIDS患者接受HAART治疗的总ADR发生率为80.8%,多发生在用药1年后,主要是血脂升高、肝肾功能异常、血液系统异常及高血糖。A组ADR发生率是86.7%,发生率最高为肾功能异常(53.3%);B组ADR发生率75%,发生率最高为血脂升高(43.3%)。结论 AIDS患者HAART方案ADR发生率高,需注意监测和对症处理,不同HAART方案ADR发生率及类型有差异,需要根据患者情况制定用药方案。OBJECTIVE To analyze the features of adverse drug reactions （ADR） in patients with AIDS during HAART treatment, and provided reference for clinical rational drug used. METHODS 120 patients with HAART admitted to a hospital from 2014 to 2015 were randomly divided into two groups, group A was lamivudine ＋ tenofovir ＋ efavirenz （3TC＋TDF＋EFV）, and group B was （ Zidovudine and Lamivudine Tablets ） ＋ efavirenz （ AZT/ 3TC ＋ EFV ）. Using the Karch and Lasagna assessment methods to assessment the adverse reactions occurred or not. And the type of adverse reactions, the emergence of time and outcome were retrospectively analyzed. RESULTS Totally, the rate of ADR was 80.8%, and almost the adverse reactions occurred in the drug using after 1 year, such as hyperch61esterolemia, liver and reral funtions, abnormality abnormal hematologic disorder and hyperglycaemia.The rate of adverse reactions in group A was 86.7%, renal disorder was the highest （53.3%）. And the rate of adverse reactions in group B was 75%, hematologic disorder was the highest （43.3%）. CONCLUSION The patient with HAART have higher drug adverse reactions, need monitoring and treatment. And the types of adverse reactions and incidence rates exit some differences, individual treatment should be carried out on the patients.

关 键 词：艾滋病 高效抗逆转录病毒治疗 不良反应 

分 类 号：R969.3[医药卫生—药理学]