芦丁β-环糊精聚合物的制备及性能研究  

Preparation and properties of Rutin β-CD polymer

作　　者：杨黎燕[1] 唐成芳[1] 张雪娇[1] 尤静[1] 罗诗琪 秦欢欢[1] 谭健聪[1] YANG Liyan TANG Chengfang ZHANG Xuejiao YOU Jing LUO Shiqi QIN Huanhuan TAN Jiancong(Institute of Pharmacology,Xi’an Medical University,Xi＇an 710021 China)

机构地区：[1]西安医学院药物研究所,陕西西安710021

出　　处：《化工科技》2017年第3期25-29,共5页Science & Technology in Chemical Industry

基　　金：国家大学生创新训练项目(201611840006);国家自然科学基金应急管理项目(81641150);陕西省教育厅基金资助项目(16JK1652)

摘　　要：以β-环糊精为原料,以载药量、包封率、综合评分为指标,考察了m(芦丁)∶m(β-环糊精聚合物微球)对载药量、包封率的影响。研究了不同m(芦丁)∶m(β-环糊精聚合物微球)在不同pH值条件下的释药情况。结果表明,当m(芦丁)∶m(β-环糊精聚合物微球)=0.02∶1时,包合效果较为理想。释药性能实验表明释药过程缓慢而持久,不同投料比释药在pH=1.2条件下总体较pH=7.4时更为缓慢,释药过程符合一级方程。β-Cyclodextrin polymer （β-CDP） were synthesized using β-cyclodextrin as raw material, by taking encapsulation rate,drug load rate and comprehensive score as index,discussed the effects of the mass ratio of β-CDP and Rutin on the inclusion effect, and the releasing was discussed respectively in different pH.Results indicated that better inclusion effect of ratio of β-CDP to Rutin was 1 ： 0.02.Ru- tin-β-CDP releasing showed the release of rutin β-CDP in pH = 1.2 was slower than pH = 7.4 with first order line equation fitting.

关 键 词：芦丁 β-CDP聚合物 释药性能 动力学方程 

分 类 号：O636.12[理学—高分子化学]