右美托咪啶对体外循环下心内直视手术患者的心肌保护作用  

Myocardial Protection Effect of Dexmedetomidine in Patients Undergoing Open-heart Surgery under CPB

作　　者：曾秋谷 黎达锋 岑相如 杨奕尤 陈显琴 林保留 谭月仙 

机构地区：[1]阳江市人民医院,广东阳江529500

出　　处：《现代医院》2017年第5期752-754,共3页Modern Hospitals

摘　　要：目的探讨右美托咪啶对体外循环下心内直视手术患者的心肌保护作用。方法选取收治的50例体外循环下心内直视手术患者,将其随机分为观察组与对照组,每组各25人。观察组注射右美托咪啶,对照组给予等容量生理盐水,在麻醉诱导前(t_0)、体外循环中30 min(t_1)和术毕(t_2)测定血清缺血修饰蛋白(IMA)和血浆肌钙蛋白Ⅰ(cTnⅠ)的浓度。结果观察组体外循环中30 min和术毕血清缺血修饰蛋白(IMA)和血浆肌钙蛋白Ⅰ(cTnⅠ)明显低于对照组,差异有统计学意义(P<0.05).结论体外循环下心内直视手术应用右美托咪啶有利于减轻心肌缺血再灌注损伤,有一定的心肌保护作用。Objective To observe the myocardial protective effect of dexmedetomidine in patients undergoing open - heart surgery under cardiopulmonary bypass （ CPB） . Methods 50 patients of open - heart surgery under CPB were random-ly divided into two groups equally, namely observation group and control group. Observation group was treated with injection of dexmedetomidine at 0. 5μg/kg for 15 min, and then maintained at 0. 4 μg/kgoh. The control group was given equal vol-ume of normal saline. Concentrations of IMA and cTnl were determined before anaesthesia （t0） , after 30 minutes of CPB （t1 ） and after surgery （ t2） . Results IMA and cTnl concentrations of tl and t2 in the observation group were significantly lower than those in the control group （P 〈0. 05） . Conclusion Dexmedetomidine has obvious protective effect on myocardi-um, which can reduce open - heart surgery of patients with myocardial ischemia reperfusion injury （ MIRI）.

关 键 词：右美托咪啶 心内直视手术 心肌保护 

分 类 号：R654.1[医药卫生—外科学]