hs-cTnT与CK-MB联合诊断小儿心肌炎的临床价值研究  

Clinical value of hs-cTnT combined with CK-MB in the diagnosis of children with myocarditis

作　　者：马桂芹[1] 李哲敏[2] 刘红伟[3] 安冀坤 王连芳[3] 田亚红[3] 

机构地区：[1]华北石油管理局总医院质控科医保办,河北任丘062450 [2]华北石油管理局总医院体检部,河北任丘062450 [3]华北石油管理局总医院儿科,河北任丘062450

出　　处：《国际检验医学杂志》2017年第11期1454-1456,共3页International Journal of Laboratory Medicine

基　　金：河北省科技厅2015年科学技术研究与发展计划项目(20150375)

摘　　要：目的研究超敏心肌肌钙蛋白T(hs-cTnT)与肌酸激酶同工酶MB(CK-MB)联合诊断小儿心肌炎的临床价值。方法于2014年11月至2015年11月,纳入心肌炎、疑似心肌损伤、排除心肌损伤(肺炎、毛细支气管炎)患儿102例,以及同期体检健康儿童50例。检测并比较患儿及健康儿童血浆hs-cTnT及CK-MB水平。结果心肌炎患儿血浆hs-cTnT与CK-MB水平均显著高于非心肌炎其他疾病患儿(P<0.05)。与健康儿童相比,心肌炎患儿hs-cTnT及CK-MB水平显著升高(P<0.05)。<1个月心肌炎患儿血浆hs-cTnT及CK-MB水平显著高于1个月至1岁及>1~3岁患儿(P<0.05)。结论 hs-cTnT与CK-MB联合检测对小儿心肌炎诊断灵敏度高、特异性强,可准确反映患儿病情,提高治疗及预后效果,值得推广应用。Objective To investigate clinical value of high sensitive-cardiac troponin T(hs-cTnT)combined with creatine kinase isoenzyme MB(CK-MB)in the diagnosis of children with myocarditis.Methods From Nov.2014 to Nov.2015,a total of 102 cases of myocarditis,suspected with myocardial damage and without myocardial damage(pneumonia and capillary bronchitis),and 50 healthy children were enrolled.Plasma levels of hs-cTnT and CK-MB were detected and compared.Results The levels of plasma hs-cTnT and CK-MB in children with myocarditis were significantly higher than those without myocarditis and healthy subjects(P<0.05).Hs-cTnT and CK-MB levels in children with myocarditis,less than one month old,were significantly higher than those with age of 1month to 3years old(P<0.05).Conclusion Combined detection of hs-cTnT and CK-MB could be with high sensitive and specificity in diagnosis of children with myocarditis,accurately assess the disease condition and improve the therapeutic effect and prognosis,which might be worthy of clinical application.

关 键 词：超敏心肌肌钙蛋白 肌酸激酶同工酶MB 心肌炎 儿童 

分 类 号：R446.1[医药卫生—诊断学] R725.4[医药卫生—临床医学]