2,1-苯并异唑的新合成方法  

New Synthetic Method of 2,1-Benzisoxazoles

作　　者：潘涛[1] 刘霞[1] 沈宏[1] 李方雷 

机构地区：[1]江苏开放大学环境与生态学院,江苏南京210036

出　　处：《化学试剂》2017年第6期675-677,680,共4页Chemical Reagents

基　　金：江苏省高校自然科学基金资助项目(16KJB150007);江苏开放大学"十二五"规划课题资助项目(14SEW-Y-006);江苏省大学生创新基金资助项目(201614000017X)

摘　　要：以硝基苯甲醛及叠氮钠为主要原料、五水硫酸铜和抗坏血酸钠为催化剂、N-甲基吡咯烷酮为溶剂(NMP),探讨溶剂种类及催化剂用量、反应温度等条件对反应的影响,"一锅法"合成苯并异唑。与传统方法相比,该方法具有原料廉价易得、底物适用性广、收率高及条件温和等特点。目标化合物结构经~1HNMR、^(13)CNMR、MS及元素分析等表征。A series of benzoisoxazoles were synthesized in a one-pot process from o-nitrobenzaldehyde and sodium azide in N- methyl pyrrolidone（NMP） with inexpensive CuSO4 ·5H2O and sodium ascorbate as the catalyst. The process has considerable ad- vantages in terms of the use of easily available suhstrates,the product diversity, the high yiled and the mild reaction conditions. The structure of the target compounds was confirmed by 1HNMR ,13 CNMR ,MS and element analysis.

关 键 词：五水硫酸铜 苯并异唑 一锅法 合成 

分 类 号：O626[理学—有机化学]