320-DVCT在评估多个血液因子与冠状动脉硬化相关性中的应用  

Correlation between multiple blood factors and severity of coronary atherosclerosis on 320 slice dynamic volume computed tomography

作　　者：李庆玲[1,2] 郭若汨[2] 周文营[3] 谢迭来[2] 康庄[2] 叶小鸣[1] 邹艳[2] 

机构地区：[1]中山大学附属第三医院特诊医疗中心,广东广州510630 [2]中山大学附属第三医院放射科,广东广州510630 [3]中山大学附属第三医院检验科,广东广州510630

出　　处：《实用放射学杂志》2017年第6期603-606,共4页Journal of Practical Radiology

基　　金：广东省科技计划重大项目（20148020225007）.

摘　　要：目的 通过320排动态容积CT（320-DVCT）检查来评估高敏C反应蛋白（hs-CRP）、血清总胆红素（Tbil）和血尿酸（BUA）对检测冠状动脉粥样硬化程度的临床价值。 方法 入选160例稳定型心绞痛患者，进行320-DVCT冠状动脉成像，根据 CT值将病变血管处斑块分为软斑块、纤维斑块、钙化斑块，同时检测患者hs-CRP、血清Tbil和BUA浓度，明确3项指标对冠状动脉病变支数、斑块性质及狭窄程度的诊断意义。对照组为100例健康者。 结果 冠心病患者随着hs-CRP、BUA浓度的升高，Tbil的浓度降低，冠状动脉病变支数及狭窄程度加重，且更容易形成软斑块。 结论 通过320-DVCT检查证实了hs-CRP、血清Tbil和BUA能准确评判冠心病患者冠状动脉病变支数、斑块性质及狭窄程度，有利于对冠状动脉粥样硬化进行风险评估。Objective To evaluate the clinical value of hs-CRP, Tbil and BUA in the diagnosis of coronary atherosclerosis on 320 slice dynamic volume computed tomography（320-DVCT）. Methods 160 patients with stable angina pectoris were included. All patients underwent 320-DVCT coronary artery imaging and laboratory testing including plasma hs-CRP, Tbil and BUA.The plaques of coronary artery were classified as soft plaque, fibrous plaque and calcified plaque on CT values. The three indicators were used to confirm the ability of diagnosis on number of lesions, plaque character and the degree of stenosis. 100 healthy persons served as the control group.Results With the concentration of hs CRP, BUA increased and Tbil concentration decreased, the number and the stenosis degree of coronary lesions became increased, and easier to form a soft plaque. Conclusion The hs-CRP, Tbil and BUA can offer the accurate diagnosis of lesions number, plaque character and stenosis degree of the coronary artery, which is showed on 320-DVCT.The hs-CRP, Tbil and BUA are conducive to the risk assessment of coronary atherosclerosis.

关 键 词：冠状动脉疾病 高敏C反应蛋白 总胆红素 血尿酸 计算机体层成像 

分 类 号：R543.3[医药卫生—心血管疾病] R814.42[医药卫生—内科学]