Graves病中IgG亚型水平的变化  

Analysis of Relationship Between IgG Subtypes and Graves' Disease

作　　者：马靖贻 张华[2] 陈彬 常曼丽[4] 刘滨菘[1] 许程琳 程昊[1] 邱明丽 崔璨[1] 

机构地区：[1]哈尔滨医科大学附属第二医院内分泌科,黑龙江哈尔滨150080 [2]山西省人民医院内分泌科,山西太原030012 [3]中国陆军总医院内分泌科,北京100700 [4]哈尔滨医科大学附属第二医院临床检验科,黑龙江哈尔滨150080

出　　处：《标记免疫分析与临床》2017年第5期486-489,494,共5页Labeled Immunoassays and Clinical Medicine

基　　金：哈尔滨医科大学附属第二医院青年基金(编号:2009BS03)

摘　　要：目的 Graves病(Graves′disease,GD)作为一种自身免疫性甲状腺疾病,其发生存在免疫调节因素的参与,目前对IgG亚类在自身免疫性甲状腺疾病(autoimmune thyroid disease,AITD)中的研究主要集中于针对血清中特定自身抗原的IgG亚型的研究,并无血清整体IgG亚型变化的相关性研究。本研究观察GD患者血清整体IgG亚型水平的变化,并对于IgG亚型与甲状腺自身抗体变化的相关性进行分析,期望通过该研究进一步了解自身抗体介导AITD的机制。方法随机收集哈尔滨医科大学附属第二医院就诊的初发GD(n=14)作为观察组,观察对象均为女性,排除其他可能影响甲状腺功能和机体免疫状态的因素。随机选取年龄、性别与观察组相匹配非甲状腺疾病健康者15例作为对照组。于清晨空腹采集患者血清,测定甲状腺功能、甲状腺自身抗体、IgG各亚型。结果 GD组血清中IgG1水平较对照组升高(P<0.05);IgG2水平也较对照组升高,但与对照组相比差异无统计学意义(P>0.05);IgG3和IgG4水平下降明显(p<0.01)。GD亚组血清IgG亚型与甲状腺自身抗体、甲状腺功能相关性分析显示各指标间无相关性(P>0.05)。结论 Graves病中存在IgG亚型水平的变化。Objective It is known that immune reaction is related to the onset Graves＇ Disease. Till now, most of studies focus on specific IgG of thyroid autoantigens, however, there is no observation on general serum IgG subtype changes in thyroid disease related to immune reaction. In the present study, we observed the change of general serum IgG subclass levels in the patients with Graves＇ Disease to discuss whether there were some correlations between serum IgG subtypes changes and thyroid autoantibodies levels, or and thyroid function changes. Methods Patients diagnosed as Graves＇ Disease （n = 14） were randomly enrolled from the Out-patient Department of the Second Affiliated Hospital of Harbin Medical University. All subjects were female. Excluding standards included all factors which could influence thyroid function and immune status. 15 cases of paired healthy women without any thyroid disease and thyroid disease family history were selected as control group. Blood samples were drawn from each patient on fast in the morning. Thyroid function, thyroid autoantibodies and IgG subclasses were assayed in each group. Results IgG subtypes levels in GD group ： Serum IgG1 level was higher than that in control group （ P 〈 0.05 ）. IgG2 level was also higher than that in control group, but there was no statistically significant difference （ P 〉 0.05 ） ; IgG4 and IgG3 levels dropped significantly compared with control group （ P 〈 0.01 ）. There was no correlation among serum IgG subtypes levels, thyroid function and thyroid autoantibodies in GD group （ P 〉 0.05 ）. Conclusion Though there were changes of IgG subtypes levels in Graves＇ Disease, there was no evidence of IgG subtypes correlated with immune onset of Graves＇ Disease.

关 键 词：GRAVES病 甲状腺自身抗体 血清IgG亚型 

分 类 号：R581.1[医药卫生—内分泌]