广州地区7340例人乳头状病毒基因分型及感染情况分析  

Analysis of 7340 cases of HPV genotypes and infection situation in Guangzhou area

作　　者：黄俊远 张战锋[2] 卢卫国[2] 周迎春[2] 

机构地区：[1]广州中医药大学,广州510403 [2]广州中医药大学第一附属医院检验科,广州510405

出　　处：《检验医学与临床》2017年第11期1576-1577,1580,共3页Laboratory Medicine and Clinic

摘　　要：目的分析广州地区人乳头状病毒(HPV)的基因分型以及感染情况,为该地区宫颈癌的预防提供指导。方法采用流体杂交和基因芯片技术检测2014年1月至2016年5月到广州中医药大学第一附属医院门诊或者体检的7 340份女性宫颈上皮细胞标本。结果总体的HPV阳性率为24.74%(1 816/7 340),阳性率最高的3种HPV基因亚型为HPV52、HPV16和HPV58,阳性率分别为5.94%(436/7 340)、4.43%(325/7 340)和3.58%(263/7 340)。有两个年龄组的HPV感染率较其他组明显升高,一组是年龄15~24岁,感染率为30.49%,而另一组为年龄>49~70岁,感染率为35.66%(P<0.05)。结论该地区HPV流行率、年龄分布和基因型分析将为HPV筛查和疫苗研究提供指导作用。Objective To analyze the genotypes of human papillomavirus（HPV） and its infection situation in Guangzhou area so as to provide a guidance for the prevention of cervical cancer in this area. Methods The flow-through hybridization and gene chip technique were used to detect 7 340 specimens of cervical epithelial cells in our hospital from January 2014 to May 2015. Results The overall HPV positive rate was 24.74%（1 816/7 340）. The three HPV sub-genotypes with highest positive rate were HPV52 （5.89%）,HPV16 （4.39%） and HPV58 （3. 56%） ,the positive rates were 5. 94%（436/7 340）,4.43%（325/7340） and 3. 58% （263/7 340）respectively. The HPV infection rate in two age groups was higher than that in the other groups,one group was the age 15- 24 years old, the infection rate was 30.49%（125/410）, and another group was the age 〉49- 70 years old, the infection rate was 35.7%（240/673） ,P〈0.05. Conclusion The HPV infection prevalence, HPV genotypes and age distribution in this area will provide a guidance role for HPV screening and vaccination research.

关 键 词：人乳头状病毒 基因分型 宫颈癌 

分 类 号：R512.91[医药卫生—内科学]