血清IL-18与胱抑素C在社区获得性肺炎伴发急性肾损伤中的诊断价值  

Diagnostic value of serum IL-18 and Cyc-C in community-acquired pneumonia complicating acute renal injury

作　　者：候茜[1] 宁沛雯[2] 

机构地区：[1]西安市儿童医院输血科,710003 [2]西安市儿童医院检验科,710003

出　　处：《检验医学与临床》2017年第11期1592-1593,1596,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨血清白细胞介素-18(IL-18)和胱抑素C(Cys-C)在社区获得性肺炎(CAP)伴发急性肾损伤(AKI)中的诊断价值。方法选取2016年1-6月于该院接受治疗的140例CAP患者作为研究对象,回顾性分析其临床资料,根据是否伴发AKI分为伴发AKI组(60例)与未伴发AKI组(80例),比较两组患者血清IL-18和Cys-C水平。然后将CAP伴发AKI组患者进行AKI分期,比较不同分期组患者血清IL-18和Cys-C水平。结果CAP伴发AKI患者血清IL-18、Cys-C水平分别为(286.32±54.06)ng/L、(3.28±0.86)mg/L,未伴发AKI组患者血清IL-18、Cys-C水平分别为(106.70±31.50)ng/L、(0.75±0.14)mg/L,组间比较显示CAP伴发AKI组患者血清IL-18、Cys-C水平明显高于未伴发AKI组患者,差异有统计学意义(P<0.05)。AKI分期后,不同AKI分期组间血清IL-18、Cys-C水平不同(P<0.05),且随着AKI分期增加,血清IL-18、Cys-C水平升高,组间比较差异均有统计学意义(P<0.05)。结论 CAP伴发AKI患者血清IL-18、Cys-C水平明显高于未伴发AKI者,且随着AKI分期增加其水平明显升高,可以作为诊断CAP伴发AKI的有效指标。Objective To investigate the diagnostic value of serum interleukinl8（IL-18） and cystatin C（Cyc-C） in community- acquired pneumonia（CAP） complicating acute kidney injury（AKI）. Methods A total of 140 patients with CAP receiving the therapy in our hospital from January to June 2016 were selected as the research subjects, and their clinical data were retrospectively ana- lyzed. The patients were divided into the complicating AKI group（n=60） and non-complicating AKI group（n=80） according to whether complicating AKI. The levels of serum IL-18 and Cyc-C were compared between the two groups. Results The levels of serum IL-18 and Cyc-C in the complicating AKI group were （286.32±54.06）ng/L and （3.28±0.86）ng/L respectively, which were significantly higher than （286.32±54.06） ng/L and （3.28±0.86） ng/L in the non-complicating AKI group, the difference was statistically significant（P〈0.05）. After AKI staging, the levels of serum IL-18 and Cyc-C were different among different AKI stages（P〈0.05） ,moreover with the AKI stage increase,serum IL-18 and Cyc-C levels were increased, the difference between the groups was statistically significant（P〈0.05）. Conclusion The levels of serum IL-18 and Cyc-C in the patients with CAP complicating AKI are significantly higher than those in the patients without complicating AKI, moreover the levels are significantly in- creased with the AKI stage increase, therefore which can serve as the effective indicators for diagnosing CAP complicating AKI.

关 键 词：社区获得性肺炎 急性肾损伤 白细胞介素18 胱抑素C 

分 类 号：R753.9[医药卫生—皮肤病学与性病学]