外周血CD_4^+CD_(25)^+Treg细胞在慢性乙型病毒性肝炎患者的表达水平及其与自身抗体的相关关系探讨  

Expression of Peripheral Blood CD_4^+CD_(25)^+Treg Cells in Patients with Chronic Hepatitis B and Its Relationship with Autoantibodies

作　　者：丘卫恩 陈允 周道祥 邝锦波 林丹 李波 

机构地区：[1]广州市越秀区中医医院,广东广州510030

出　　处：《临床医学工程》2017年第6期801-802,共2页Clinical Medicine & Engineering

摘　　要：目的探讨外周血CD_4^+CD_(25)^+调节性T细胞(Treg细胞)在慢性乙型病毒性肝炎(CHB)患者中的表达水平及其与自身抗体的关系。方法选取2013年1月至2015年12月于我院首次就诊且未做任何治疗的CHB患者156例,分为A组(自身抗体阳性组,70例)和B组(自身抗体阴性组,86例)。同时,选取同期来院行健康查体的正常人50例作为C组。结果 A组的CD_4^+CD_(25)^+T细胞数显著低于B组和C组(P<0.05)。A组的HBV-DNA和ALT水平均显著高于B组(P<0.05)。随着外周血CD_4^+CD_(25)^+Treg细胞百分数的增加,自身抗体数逐渐降低,二者呈显著负相关关系(r=-0.519,P<0.05)。结论 CD_4^+CD_(25)^+Treg细胞可能具有抑制CHB患者产生自身抗体的作用,可避免机体免疫耐受的产生和发展,从而达到减轻肝炎病情的目的。Objective To investigate the expression of CD4＋ CD25＋Treg cells in patients with chronic viral hepatitis B （CHB） and its relationship with autoantibodies. Methods 156 CHB patients treated for the first time in our hospital from January 2013 to December 2015 were divided into group A （autoantibody-positive group, 70 cases） and group B （antibody-negative group, 86 cases）. 50 cases at the same period to our hospital for normal physical examination were selected as group C. Results The number of CD4＋CD25＋Treg cells in group A was significantly lower than that in group B and C （P〈0.05）. The levels of HBV-DNA and ALT in group A were significantly higher than those in group B （P〈0.05）. With the increase of CD4＋CD25＋Treg cells in peripheral blood, the number of autoantibodies decreased gradually, with a negative correlation between them （r = -0.519, P〈0.05）. Conclusions CD4＋CD25＋Treg cells may inhibit the production of autoantibodies in CHB patients and prevent the development of immune tolerance, so as to achieve the purpose of reducing the severity of hepatitis.

关 键 词：CD4+CD25+TREG细胞 乙型病毒性肝炎 自身抗体 

分 类 号：R512.62[医药卫生—内科学]