钩藤生物碱闪式提取工艺研究  

Optimizing Homogenate Extraction Process for Alkaloids of Ramulus Uncariae by Uniform Design

作　　者：王海波[1] 邸学[1] 谭超元[1] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600

出　　处：《辽宁中医药大学学报》2017年第6期51-53,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81102789);辽宁中医药大学杏林杰出青年基金项目(JQ20081228)

摘　　要：目的:确定闪式提取钩藤药材生物碱成分的最佳工艺条件。方法:运用均匀试验设计,以提取液中去氢钩藤碱、异去氢钩藤碱含量及出膏率为指标,采取多指标综合评分法结合主成分分析,对闪式提取的影响因素进行考察。结果:闪式提取的最佳工艺是:将钩藤药材粉碎,加入75%乙醇溶剂的料液比为1:50,提取时间50 s;出膏率10.1%,两种生物碱成分总量0.53 mg/g。结论:采取闪式提取法进行钩藤生物碱的提取,提取效率高,提取工艺操作简便、快速,更利于保持钩藤生物碱类成分稳定。Objective ： The research aimed to optimize the extraction techniques for Ramulus Uncariae Cure Uncis with homogenate extraction. Methods ： The extraction techniques was optimized by multi-index text comprehensive scoring method and principal component analysis, the use of uniform design, which took the extraction rate of corynoxeine content, isocorynoxeine content and rate of creaming as indices. Results ： The optimum extracting procedure was extracting 50 s, using 50 times volume of 75% alcohol. Conclusion ： The extraction technique is simple and quick, with high extracting rate.

关 键 词：闪式提取 钩藤 生物碱 均匀设计 

分 类 号：R284.2[医药卫生—中药学]