柴胡疏肝散治疗甲状腺功能亢进症近期疗效及远期复发率观察  

Observation of the Short-term Effects and Long-term Recurrence Rate of Chaihu Shugan San in the Treatment of Hyperthyroidism Thyroid Function

作　　者：邓翠 李京[2,3] 汤秀珍 

机构地区：[1]本溪市中医院,辽宁本溪117000 [2]沈阳军区总医院,辽宁沈阳110840 [3]宽甸满族自治县中医院,辽宁宽甸118200

出　　处：《辽宁中医药大学学报》2017年第6期107-110,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：辽宁省科技厅科研基金项目(2012225018);辽宁省科学技术基金项目(20092038)

摘　　要：目的:探讨柴胡疏肝散治疗甲状腺功能亢进症的近期疗效及远期复发率。方法:选取我院内分泌科收治的甲状腺功能亢进症患者94例,按随机数字表法分组,对照组47例予以甲巯咪唑治疗,研究组47例在对照组基础上予以柴胡疏肝散治疗,观察并记录两组间甲状腺功能、抗氧化能力指标水平,同时对比近期临床疗效、远期复发率及不良反应发生率。结果:对照组治疗有效率63.83%低于研究组治疗有效率82.98%,对照组远期复发率为72.72%高于研究组远期复发率30.00%,具有统计学意义(P<0.05);与对照组比较,研究组治疗后血清FT3、FT4、TT3、TT4水平降低,血清TSH水平升高,治疗后血清TRAb、TG、TMAb、TGAb水平降低,治疗后血清T-AOC、MPO、SOD水平升高,血清MDA水平降低,具有统计学意义(P<0.05);研究组不良反应发生率8.51%低于对照组23.39%,具有统计学意义(P<0.05)。结论:柴胡疏肝散可以改善甲状腺功能亢进症患者甲状腺功能,提高抗氧化能力,有效提高近期疗效,减少复发,而且安全性较高。Objective ： To investigate the short-term effects and long-term recurrence rate of Chaihu .Shugan San in the treatment of hyperthyroidism thyroid function. Methods ： 94 patients with hyperthyroidism thyroid function from the department of endocrinology in our hospital were selected and divided into 2 groups,47 cases in the control group received Methimazole treatment,47 cases in the experiment group received Chaihu Shugan San on the basis of the control group, levels of thyroid function index, antioxidant capacity index, short-term clinical curative effect, long-term recurrence rate and incidence of adverse reactions were compared after the treatment. Results ： The effective rate in the control group （ 63.83% ） was lower than the experiment group （ 82.98% ）, the long-term recurrence rate in the control group （ 72.72% ） was higher than the experiment group （ 30.00% ）, with significant difference （ P〈0.05 ）; compared with the control group, serum levels of FT3, FT4, TT3, TT4 decreased, serum level of TSH increased after treatment in the experiment group, serum levels of TRAb, TG, TMAb, TGAb decreased after treatment, serum levels of T-AOC, MPO, SOD increased, serum level of MDA decreased after treatment, with significant difference （ P〈0.05 ）; the incidence of adverse reactions in the experiment group （ 8.51% ）was lower than the control group （ 23.39% ）, with significant difference （ P〈0.05 ）. Conclusion ： Chaihu Shugan San can improve thyroid function in patients with hyperthyroidism thyroid function, increase antioxidant capacity, effectively improve the short-term efficacy, reduce the recurrence, and the safety is high.

关 键 词：柴胡疏肝散 甲状腺功能亢进症 近期疗效 远期复发率 

分 类 号：R581.1[医药卫生—内分泌]