腹针对奥氮平所致肥胖脂代谢的影响  

Impacts of abdominal acupuncture on lipid metabolism in olanzapine-induced obesity

作　　者：张蕾[1] 丁瑛[1] 张丽娜[1] 孙国庆[1] 吴哲[1] 

机构地区：[1]杭州市第七人民医院精神科,浙江杭州310013

出　　处：《中国针灸》2017年第6期591-593,共3页Chinese Acupuncture & Moxibustion

基　　金：浙江省中医药科学研究基金计划项目:2012 ZB 135

摘　　要：目的:探讨腹针对奥氮平所致肥胖患者血清瘦素、脂联素、总胆固醇及三酰甘油的影响。方法:将86例奥氮平所致肥胖患者随机分为观察组(47例)和对照组(39例)。对照组仅予以健康指导,接受饮食及运动调节;观察组在对照组基础上增加腹针疗法,穴取中脘、下脘、气海、关元、天枢、水道,每天治疗1次,每周治疗5次。两组均治疗3个月。比较两组患者治疗前后体质量指数(BMI)、血清瘦素、脂联素、总胆固醇及三酰甘油水平。结果:治疗后两组患者BMI、血清瘦素、总胆固醇和三酰甘油均低于治疗前(均P<0.05),脂联素高于治疗前(均P<0.05),并且观察组BMI、血清瘦素、总胆固醇和三酰甘油明显低于对照组(均P<0.05),脂联素高于对照组(P<0.05)。结论:腹针能调节奥氮平所致肥胖患者瘦素信号的转导能力以及脂联素的分泌,促进脂代谢,降低患者体质量。Objective To discuss the impacts of abdominal acupuncture on serum leptin, adiponectin, total cholesterol and triglyceride in the patients of obesity induced by olanzapine. Methods Eighty-six obesity patients induced by olanzapine were randomized into an observation group（47 cases） and a control group（39 cases）. The healthcare guide and the adjustment on diet and physical exercise were given in the two groups. Additionally, in the observation group, the abdominal acupuncture therapy was applied to Zhongwan（CV 12）, Xiawan（CV 10）, Qihai（CV 6）, Guanyuan（CV 4）, Tianshu（ST 25） and Shuidao（ST 28）, once a day,5 times a week. The treatment lasted for 3 months in the two groups. The body mass index（BMI）, serum leptin, adiponectin, total cholesterol and triglyceride were compared before and after treatment in the patients of the two groups. Results After treatment,BMI, serum leptin, total cholesterol and triglyceride were all lower than those before treatment in the patients of the two groups（all P〈0.05）. Adiponectin was higher than that in the two groups before treatment（both P〈0.05）. After treatment, BMI, serum leptin, total cholesterol and triglyceride in the observation group were apparently lower than those in the control group（all P〈0.05） and adiponectin was higher than that in the control group（P〈0.05）. Conclusion Abdominal acupuncture regulates the transfer capacity of leptin signal and the secretion of adiponectin, promotes lipid metabolism and reduces the body mass in obesity patients induced by olanzapine.

关 键 词：肥胖 腹针 奥氮平 脂代谢 

分 类 号：R246.1[医药卫生—针灸推拿学]