兔急性脊髓损伤的DTI扩散参数及病理对照  

A comparative study of diffusion tensor imaging parameters and pathologic changes in rabbit with acute spinal cord injury

作　　者：赵细辉 陈昆涛[2] 王荣品[1] 王骋[1] 

机构地区：[1]贵州省人民医院放射科,贵阳市550002 [2]遵义医学院第五附属(珠海)医院放射科,广东省珠海市519100

出　　处：《实用医学杂志》2017年第10期1597-1600,共4页The Journal of Practical Medicine

基　　金：贵州省科学技术基金项目(编号:黔科合J字LKZ[2010]52号)

摘　　要：目的:制作兔急性脊髓损伤模型,探讨磁共振张量成像(DTI)对早期ASCI定量诊断的可行性及准确性。方法:30只中国大耳白兔,随机抽取24只作为实验组,另6只作为对照组。实验组采用改良Allen′s打击法制成中度急性脊髓损伤;对照组仅暴露脊膜,不损伤脊髓。在造模后第1、3、5、7天行常规MRI、DTI扫描、扩散张量纤维束成像(DTT)图像后处理,于MRI检查完毕,取兔脊髓进行病理检查。结果:实验组各时间点炎性细胞数目、脊髓大型运动神经元数目与表观弥散系数(ADC)值、各向异性分数(FA)值呈明显的相关关系。DTT图像显示脊髓出现缺损、卷曲、断裂等征象。结论:DTI的参数(FA值、ADC值)可反映急性脊髓损伤早期病理变化,临床上可将DTI作为急性脊髓损伤的评价方法之一。Objective To make spinal cor injury model of rabbit in order to investigate the feasibility and accuracy of diffusion tensor imaging in diagnosis of early ASCI. Methods In 30 Chinese rabbits, 24 rabbits were randomly selected as the experimental group and the other 6 as the control group. Allen＇s technique were used to make moderateacute spinal cord injury in the experimental group. In the control group, the operation only exposed the spinal membrane, wihthout damage on the spinal cord. All rabbits were performed in routine MRI, DTI, diffusion tensor tractography and post-processing. After the MRI scan, the rabbit spinal cord was removed to have pathological examination at 1, 3, 5, 7 days. Results The number of inflammatory ceils and spinal motor neurons were closely correlated with FA values and ADC values. DTT images showed the spinal cord defects, curling and breaking. Conclusion The parameters of DTI （FA, ADC） can reflect the pathological changes of acute spinal cord injury in early stage, and therefore may be used as an routine evaluation method for clinical acute spinal cord injury.

关 键 词：脊髓损伤 磁共振张量成像 模型 动物 兔 

分 类 号：R445.2[医药卫生—影像医学与核医学]