不同BMI的2型糖尿病患者心血管等靶器官功能损伤的风险评估  

Risk assessment of cardiovascular and other target organs damage in patients with type 2 diabetes and different body mass indexes

作　　者：杨宏伟[1] 张幽幽[1] 王丽君[1] 

机构地区：[1]浙江省台州市第一人民医院内分泌科,318020

出　　处：《重庆医学》2017年第16期2218-2220,2223,共4页Chongqing medicine

摘　　要：目的探讨不同体质量指数(BMI)的2型糖尿病患者心血管等靶器官功能损伤的风险。方法自2014年1月至2016年1月前瞻性收集该院收治的2型糖尿病患者126例,其中研究组(BMI≥25kg/m2)57例,对照组(18.5kg/m2≤BMI<25kg/m2)69例。分析两组患者的临床特征,并分析BMI与靶器官损伤相关指标[颈动脉内膜中膜厚度(IMT)、动脉硬化指数、冠心病指数和肾小球滤过率]的相关性。结果两组患者空腹血糖差异无统计学意义(P=0.953),研究组患者BMI显著高于对照组(P=0.000)。与对照组比较,研究组患者年龄显著增加(P=0.038);收缩压显著增加(P=0.000);糖尿病家族史显著增加(P=0.000);总胆固醇显著增加(P=0.012);三酰甘油显著增加(P=0.000);高密度脂蛋白显著降低(P=0.003);HOMA-IR水平显著升高(P=0.000);HOMA-β水平显著降低(P=0.000);IMT水平显著升高(P=0.000);动脉硬化指数显著升高(P=0.000);冠心病指数显著升高(P=0.001);肾小球滤过率显著降低(P=0.000)。Pearson直线相关分析显示BMI与IMT、动脉硬化指数、冠心病指数和肾小球滤过率相关,r值分别为0.234、0.257、0.294和0.211(均P=0.000)。结论 2型糖尿病患者BMI水平与心血管和肾功能损伤有关。Objective To investigate the risk of cardiovascular and other target organs damage in the patients with type 2 di- abetes mellitus（T2DM） and different body mass indexes （BMI）. Methods One hundred and twenty-six patients with T2DM admit- ted to our hospital from January 2014 to January 2016were prospectively collected,including 57 cases in the study group （BMI≥25 kg/m2） and 69 cases in the control group （18.5 kg/m2 ≤BMI〈25 kg/m2）. The clinical features of the two groups were analyzed, and the correlation between BMI and related indexes of target organ damage [carotid artery intima media thickness （IMT）, arterial stiffness index,coronary heart disease index and glomerular filtration rate] were analyzed. Results There was no statistically sig- nificant difference in fasting blood giucose between the two groups （P= 0. 953）,BMI in the study group was significantly higher than that in the control group （P=0. 000）. When compared with the control group, the study group showed a significantly increase in age （P=0. 038）,a significant increase in systolic blood pressure （P=0. 000）;a significantly increase in diabetic family history （P= 0. 000） ; a significant increase m total cholesterol （P= 0. 012） ; a significant increase in triglycerides （P = 0. 000）, a significant decrease in high density lipoprotein （P= 0. 003）;a significant increase in HOMA-IR level （P= 0. 000）;a significant decrease in HOMA- 13 level （P=0. 000）;a significant increase in IMT level （P=0. 000）;a significant increase in arterial stiffness index （P= 0. 000）;a significant increase in coronary heart disease index （P= 0. 001）; and a significant decrease in glomerular filtration rate （P=0. 000）. The Pearson linear correlation analysis showed that BMI was correlated with IMT, atherosclerosis index, coronary heart disease index and glomerular filtration rate, the r values were 0. 234,0. 257,0. 294 and 0. 211 respectively（all P = 0. 000）. Con- clusion The BMI level in the patie

关 键 词：BMI指数 2型糖尿病 靶器官功能 风险评估 

分 类 号：R587.2[医药卫生—内分泌]