丹蛭降糖胶囊对早期糖尿病肾病患者血清TIMP-2、CRP、ACR表达的影响  

The Influence of Danzhi Jiangtang Capsule on the Expression of TIMP-2 and hs-CRP in Serum of Patients with Diabetes Mellitus

作　　者：李中南[1] 熊园园[2] 邢宇婷 窦德梅 

机构地区：[1]安徽中医药大学第一附属医院,安徽合肥230031 [2]安徽中医药大学,安徽合肥230031

出　　处：《中医药临床杂志》2017年第5期674-677,共4页Clinical Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局公共卫生服务平台建设项目;国家中医药管理局基地建设科研专项第一批(JDZX2012001);第二批(JDZX2015123);国家自然科学基金立项(81573944);基于信息化管理的社区IGT八段锦干预及推广应用研究(15011d04010)

摘　　要：目的:观察丹蛭降糖胶囊对早期糖尿病肾病(DKD)患者血清TIMP-2、hs-CRP、ACR的影响。方法:纳入符合标准的糖尿病患者60例,其中西药组32例,丹蛭组28例,2组均采用西医综合治疗方案,丹蛭组在西药基础上加用丹蛭降糖胶囊。另纳入健康体检者30例作为对照组。3个月后抽取清晨空腹静脉血,测血糖、糖化血红蛋白、肾功能、高敏C反应蛋白(hs-CRP),ELISA法测算TIMP-2值,检测尿白蛋白肌酐比值(ACR)。结果:与对照组比较,西药组和丹蛭组TIMP-2和hs-CRP的表达均明显升高(P<0.01),用药后,丹蛭组TIMP-2、hs-CRP的表达显著于低于西药组(P<0.01或P<0.05);相关性分析提示TIMP-2与hs-CRP及糖化血红蛋白均呈正相关,相关性系数分别为r=0.655,r=0.402;hs-CRP、ACR与糖化血红蛋白呈正相关,相关性系数为r=0.366;r=0.415。结论:丹蛭降糖胶囊能抑制TIMP-2、hs-CR和ACR的高表达,对于延缓早期糖尿病肾病的发生发展有重要意义。Objective： To observe the effect of Danzhi Jiangtang Capsule on serum TIMP-2, hs-CRP and ACR in patients with early diabetic nephropathy （DKD）. 60 patients who meet the inclusion criteria were randomly divided into the western group （32cases） and Danzhi group （30cases）. 2 groups were treated with Western medicine comprehen- sive treatment program, Danzhi Jiangtang capsule was used in the Danzhi group as addition. 30 healthy subjects were selected as the control group. 3 months later, extract the morning fasting venous blood. Blood glucose, glycosylated hemoglobin, and renal function, high sensitivity C - reactive protein （hs-CRP） was measured. The TIMP-2 and urinary albumin creatinine ratio （ACR） were measured by ELISA. Results： Compared with the control group, the expression of TIMP-2 and hs-CRP in the western medicine group and Danzhi group were significantly increased （P 〈0.01）. The ex- pression of TIMP-2 and hs-CRP in Danzhi group was significantly lower than that in western medicine group （P 〈0.01 or P 〈0.05）. Correlation analysis showed that TIMP-2 was positively correlated with hs-CRP and glycosylated hemo- globin, and the correlation coefficients were R = 0.655, r =0.402; hs-CRP, ACR and glycosylated hemoglobin were positively correlated, the correlation coefficient r=0.366; r=0.415. Conclusion： Danzhi Jiangtang Capsule can inhibit the expression of TIMP-2, hs-CR and ACR, which is important for delaying the development of early diabetic nephropathy.

关 键 词：TIMP-2 HS-CRP ACR 糖化血红蛋白 丹蛭降糖胶囊 糖尿病 

分 类 号：R255.4[医药卫生—中医内科学]